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- W1535249103 abstract "Two lines of mice bred for their susceptibility and resistance to sensitization by the histamine sensitizing factor of Bordetella pertussis , and designated as HSFS/N and HSFR/N, respectively, are described and characterized after 14 generations of selective breeding. The lines were derived from the N:HIH(SW) mouse strain with the ultimate purpose of providing genetically uniform mice with predictable characteristics, that are easily immunized by pertussis vaccine and have low variability in their response. Mice of the HSFS/N line were more easily sensitized to HSF, more immunizable with pertussis vaccine, less susceptible to intra-cerebral challenge by B. pertussis and less susceptible to Escherichia coli endotoxin and histamine diphosphate toxicity than were HSFR/N mice. The two lines responded similarly in the mouse weight gain test and did not differ in serum histaminase levels or susceptibility to passive anaphylaxis." @default.
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- W1535249103 date "1975-01-01" @default.
- W1535249103 modified "2023-10-14" @default.
- W1535249103 title "Selective breeding to establish a standard mouse for pertussis vaccine bioassay" @default.
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- W1535249103 doi "https://doi.org/10.1016/0092-1157(75)90060-8" @default.
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