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- W1535250353 abstract "The DNA sequence of the encoding gene predicts a unique structure for guinea‐pig gonadotropin‐releasing hormone (GnRH). We assessed the immunoreactivity of synthetic mammalian GnRH, of a synthetic peptide with predicted guinea‐pig GnRH structure, and of extracts from rat and guinea‐pig hypothalami, using two different RIA systems. Whereas immunoreactivity of mammalian and guinea‐pig GnRH was rather similar when using an antiserum with conformational specificity for mammalian GnRH (Root RR‐5 antiserum), binding of both peptides to an antiserum with sequential specificity (Kelch R‐13 antiserum) was markedly different. The findings for GnRH extracted from rat and guinea‐pig hypothalami were similar to those for the corresponding synthetic peptides. Assessment of in‐vivo biological activity of synthetic mammalian and guinea‐pig GnRH in the intact male guinea‐pig showed that both peptides stimulate LH secretion dose‐dependently, the response to mammalian GnRH being slightly greater at low dose. This study confirms that the GnRH expressed in the brain of the adult guinea‐pig differs from mammalian GnRH and indicates that mammalian and guinea‐pig GnRH display conformational similarity and that both can stimulate guinea‐pig luteinizing hormone secretion." @default.
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- W1535250353 date "2000-04-01" @default.
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- W1535250353 title "Guinea-Pig Gonadotropin-Releasing Hormone: Immunoreactivity and Biological Activity1" @default.
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- W1535250353 doi "https://doi.org/10.1046/j.1365-2826.2000.00472.x" @default.
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