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• W1535393901 abstract "Primary varicella in pregnancy may cause serious maternal morbidity and mortality and is associated with Fetal Varicella Syndrome (FVS). Checking for varicella antibodies in those with no history or an uncertain history of exposure to chicken pox pre-pregnancy is not currently a national screening recommendation in the UK. In the North-west of London, over 80% of our drainage population is non-Caucasian and the rate of seronegativity at the start of pregnancy may be higher. The aim of our review was to ascertain prevalence of primary varicella infection in pregnancy in our population and compare management with RCOG recommendations. A retrospective review was carried out for the period February 2012- February 2013 using our fetal medicine software ‘Astria’ and blood results were accessed using local trust-wide online results system. Details were cross checked with a register maintained in the fetal medicine unit (FMU). Out of 30 women identified with varicella exposure, data for 28 was available. 64% of these women were in the 20–30 years age group and 57% were primiparous. 50% were exposed at a gestation of <13 weeks, 25% between 13–20 weeks and around 11% at >20 weeks. 14 out of 28 women were found to be non-immune (50%). VZIg was only documented as given in 9 of these cases. Nine women went on to develop chicken pox but only 7 were given Aciclovir. All these women were referred to FMU and overall 72 scans were performed for them. 75% of them were normal. Detected abnormalities included: Increased nuchal fold thickness (2), Echogenic bowel (2), Oligohydramnios (1), Polyhydramnios (1) and Ventricular ectopic beats (1). Although a recent study demonstrated cost effectiveness of antenatal varicella screening, this is not currently part of UK screening programme. Ultrasound monitoring of exposed pregnancies places considerable burden on FMU workload. Compliance with unit policy in prompt availability of VZIg and Aciclovir for suitable women in our unit was suboptimal." @default.
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• W1535393901 date "2013-10-01" @default.
• W1535393901 modified "2023-09-26" @default.
• W1535393901 title "P02.05: Prevalence and management of primary varicella infection in pregnancy in a North-West London hospital" @default.
• W1535393901 doi "https://doi.org/10.1002/uog.12923" @default.
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