Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535486910> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1535486910 endingPage "29" @default.
- W1535486910 startingPage "619" @default.
- W1535486910 abstract "Cultured bovine lens epithelial cells (BLECs) exposed to sodium hypertonicity respond with an accumulation of intracellular myo-inositol. Using BLECs initially maintained at hypertonicity and reacting to a decrease in medium osmolality, a mechanism for the tonicity-activated release of myo-inositol was recognized. Alternatively, BLECs acclimated to sodium hypertonicity and subsequently transferred to high sodium osmolality plus hypergalactosemia rapidly accumulate intracellular galactitol, an experimental manipulation that permitted characterization of the role of sugar alcohols in polyol-activated myo-inositol efflux. The authors identify a communal transport route for tonicity-activated and polyol- activated myo-inositol release from cell to medium and demonstrate an association for myo-inositol efflux with chloride movement.Two distinct experimental approaches were designed to delineate the physiological circumstances that initiate myo-inositol efflux. For tonicity-induced inositol efflux, BLECs were maintained at confluence in sodium hypertonic medium (473+/-6 mOsm) for 48 hours; afterward, the medium was replaced with isotonic medium (285+/-4 mOsm) containing 40 mM galactose +/- Sorbinil. For polyol-induced inositol release, hypertonically adapted BLECs were transferred to fresh sodium hypertonic medium containing 40 mM galactose (513+/- 10 mOsm).On reduction in medium osmolality, intracellular myo-inositol was lost because of a rapid, transient efflux during the first 30 minutes, which was followed by a slow, sustained decrease in efflux during the next 12 hours. Inhibition of aldose reductase activity substantially diminished myo-inositol efflux from cell to galactose-containing, isotonic medium. Administration of phloretin significantly inhibited both tonicity-activated and polyol-activated myo-inositol release, as did the chloride channel blocker, niflumic acid.In cultured bovine lens epithelial cells, tonicity-activated movement of myo-inositol from cell to medium and myo-inositol efflux as induced by intracellular polyol accumulation appear to be interactively associated with chloride movement and moderated by a common anionic (chloride) channel, carrier-mediated transport protein, or both." @default.
- W1535486910 created "2016-06-24" @default.
- W1535486910 creator A5009214738 @default.
- W1535486910 creator A5017356760 @default.
- W1535486910 date "1996-03-01" @default.
- W1535486910 modified "2023-09-23" @default.
- W1535486910 title "Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 5. Mechanism of the myo-inositol efflux pathway." @default.
- W1535486910 cites W111825583 @default.
- W1535486910 cites W1600435167 @default.
- W1535486910 cites W1653215310 @default.
- W1535486910 cites W17115755 @default.
- W1535486910 cites W1947692468 @default.
- W1535486910 cites W194851151 @default.
- W1535486910 cites W1967215694 @default.
- W1535486910 cites W1996845076 @default.
- W1535486910 cites W2024400482 @default.
- W1535486910 cites W2057256112 @default.
- W1535486910 cites W2058660539 @default.
- W1535486910 cites W2075120289 @default.
- W1535486910 cites W2128635872 @default.
- W1535486910 cites W2172128865 @default.
- W1535486910 cites W2274088425 @default.
- W1535486910 cites W2287121189 @default.
- W1535486910 cites W2300388399 @default.
- W1535486910 cites W2344907336 @default.
- W1535486910 cites W2406075271 @default.
- W1535486910 cites W37652429 @default.
- W1535486910 cites W50458594 @default.
- W1535486910 cites W50517463 @default.
- W1535486910 cites W8036984 @default.
- W1535486910 cites W98532952 @default.
- W1535486910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8595962" @default.
- W1535486910 hasPublicationYear "1996" @default.
- W1535486910 type Work @default.
- W1535486910 sameAs 1535486910 @default.
- W1535486910 citedByCount "10" @default.
- W1535486910 countsByYear W15354869102013 @default.
- W1535486910 countsByYear W15354869102014 @default.
- W1535486910 crossrefType "journal-article" @default.
- W1535486910 hasAuthorship W1535486910A5009214738 @default.
- W1535486910 hasAuthorship W1535486910A5017356760 @default.
- W1535486910 hasConcept C117277713 @default.
- W1535486910 hasConcept C129513315 @default.
- W1535486910 hasConcept C129900496 @default.
- W1535486910 hasConcept C134018914 @default.
- W1535486910 hasConcept C14705128 @default.
- W1535486910 hasConcept C170493617 @default.
- W1535486910 hasConcept C178790620 @default.
- W1535486910 hasConcept C185592680 @default.
- W1535486910 hasConcept C18903297 @default.
- W1535486910 hasConcept C200082930 @default.
- W1535486910 hasConcept C2776241147 @default.
- W1535486910 hasConcept C2777427919 @default.
- W1535486910 hasConcept C2778173381 @default.
- W1535486910 hasConcept C537181965 @default.
- W1535486910 hasConcept C55493867 @default.
- W1535486910 hasConcept C58415070 @default.
- W1535486910 hasConcept C79879829 @default.
- W1535486910 hasConcept C86803240 @default.
- W1535486910 hasConceptScore W1535486910C117277713 @default.
- W1535486910 hasConceptScore W1535486910C129513315 @default.
- W1535486910 hasConceptScore W1535486910C129900496 @default.
- W1535486910 hasConceptScore W1535486910C134018914 @default.
- W1535486910 hasConceptScore W1535486910C14705128 @default.
- W1535486910 hasConceptScore W1535486910C170493617 @default.
- W1535486910 hasConceptScore W1535486910C178790620 @default.
- W1535486910 hasConceptScore W1535486910C185592680 @default.
- W1535486910 hasConceptScore W1535486910C18903297 @default.
- W1535486910 hasConceptScore W1535486910C200082930 @default.
- W1535486910 hasConceptScore W1535486910C2776241147 @default.
- W1535486910 hasConceptScore W1535486910C2777427919 @default.
- W1535486910 hasConceptScore W1535486910C2778173381 @default.
- W1535486910 hasConceptScore W1535486910C537181965 @default.
- W1535486910 hasConceptScore W1535486910C55493867 @default.
- W1535486910 hasConceptScore W1535486910C58415070 @default.
- W1535486910 hasConceptScore W1535486910C79879829 @default.
- W1535486910 hasConceptScore W1535486910C86803240 @default.
- W1535486910 hasIssue "4" @default.
- W1535486910 hasLocation W15354869101 @default.
- W1535486910 hasOpenAccess W1535486910 @default.
- W1535486910 hasPrimaryLocation W15354869101 @default.
- W1535486910 hasRelatedWork W1489998492 @default.
- W1535486910 hasRelatedWork W1511990109 @default.
- W1535486910 hasRelatedWork W1535486910 @default.
- W1535486910 hasRelatedWork W17115755 @default.
- W1535486910 hasRelatedWork W2015995808 @default.
- W1535486910 hasRelatedWork W2029437886 @default.
- W1535486910 hasRelatedWork W2063199566 @default.
- W1535486910 hasRelatedWork W2093722379 @default.
- W1535486910 hasRelatedWork W2220205074 @default.
- W1535486910 hasRelatedWork W2261588185 @default.
- W1535486910 hasVolume "37" @default.
- W1535486910 isParatext "false" @default.
- W1535486910 isRetracted "false" @default.
- W1535486910 magId "1535486910" @default.
- W1535486910 workType "article" @default.