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• W1535492056 abstract "Genes expressed during development regulate the emergent structure and function of the growing brain. Genetic mechanisms interact with environmental influences to predispose individuals to structural and functional brain disorders. The embryological sequence of nervous system development is relatively well understood. Longitudinal neuroimaging studies have highlighted that prolonged postnatal brain change is associated with acquisition of higher level cognitive skills such as language, memory and executive function. However, understanding of developmental neurobiology has not yet been extensively integrated with systems neuroscience, to identify key molecular and cellular mechanisms relevant to human cognition. Furthermore, little is known about genetic variants that constrain embryological and later brain development to influence neurological and cognitive outcomes in developmental disabilities and psychiatric disorders. Following the completion of the Human Genome Project, new technologies have enabled an extraordinary expansion in knowledge of genetic sequence variation, gene expression and epigenetics. Establishing convergence between developmental biology, systems neuroscience and genomics to understand the neurobiological bases for neurodevelopmental disorders remains an exciting challenge for the next decades.Key Concepts: Brain development involves differentiation of highly specialised cell types, in predictable temporal sequences, and their organisation into precise spatial systems.Genetic variation interacts with environmental influences to predispose individuals to structural and functional brain disorders, by influencing developmental mechanisms.Major events in early nervous system development include induction of the neural plate, neurogenesis, differentiation of neuronal and glial cell types, and migration of cells into their correct position.Postnatal brain development, including maturation of white matter tracts and synaptic pruning in response to stimulation and behaviour, is also important, but the neurobiology is much less well understood.Both early and later developmental processes may be disrupted by genetic mutations or influenced by sequence variation, but links from gene to brain to cognitive functions are complex and require investigation by convergent methods.New methods of investigating genomic organisation and the structure and function of the living human brain are increasingly being integrated to elucidate molecular and cellular mechanisms of relevance to neurodevelopmental disorders.Keywords:development;brain;neurodevelopmental;neurobiology;disorders" @default.
• W1535492056 created "2016-06-24" @default.
• W1535492056 creator A5051221846 @default.
• W1535492056 creator A5088503779 @default.
• W1535492056 date "2010-09-15" @default.
• W1535492056 modified "2023-09-23" @default.
• W1535492056 title "Brain: Neurodevelopmental Genetics" @default.
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• W1535492056 doi "https://doi.org/10.1002/9780470015902.a0005145.pub2" @default.
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