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- W1535627390 abstract "Graves' orbitopathy (GO), also known as thyroid eye disease is an inflammatory disease of the orbital tissue of the eye that arises as a consequence of autoimmune thyroid disease. The central feature of the disease is the production of antibodies to the thyrotropin hormone receptor (TSHR) that modulate the function of the receptor leading to autoimmune hyperthyroidism and GO. Over the years, all viable preclinical models of Graves' disease have been incomplete and singularly failed to progress in the treatment of orbital complications. A new mouse model of GO based upon immunogenic presentation of human TSHR A-subunit plasmid by close field electroporation is shown to lead to induction of prolonged functional antibodies to TSHR resulting in chronic disease with subsequent progression to GO. The stable preclinical GO model exhibited pathologies reminiscent of human disease characterized by orbital remodeling by inflammation and adipogenesis. Inflammatory lesions characterized by CD3+ T cells and macrophages were localized in the orbital muscle tissue. This was accompanied by extensive adipogenesis of orbital fat in some immune animals. Surprisingly, other signs of orbital involvement were reminiscent of eyelid inflammation involving chemosis, with dilated and congested orbital blood vessels. More recently, the model is replicated in the author's independent laboratories. The pre-clinical model will provide the basis to study the pathogenic and regulatory roles of immune T and B cells and their subpopulations to understand the initiation, pathophysiology, and progression of GO." @default.
- W1535627390 created "2016-06-24" @default.
- W1535627390 creator A5027255737 @default.
- W1535627390 creator A5036004952 @default.
- W1535627390 creator A5065739010 @default.
- W1535627390 creator A5074461515 @default.
- W1535627390 date "2015-08-19" @default.
- W1535627390 modified "2023-10-14" @default.
- W1535627390 title "Modeling Graves’ Orbitopathy in Experimental Graves’ Disease" @default.
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- W1535627390 doi "https://doi.org/10.1055/s-0035-1555956" @default.
- W1535627390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26332756" @default.
- W1535627390 hasPublicationYear "2015" @default.
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