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• W1535667752 endingPage "114" @default.
• W1535667752 startingPage "77" @default.
• W1535667752 abstract "The pharmacological targeting of different phosphodiesterase (PDE) isoforms is predicted to have diverse, isoform-specific effects on central nervous system (CNS) function, and some of these effects may be relevant to the treatment of psychiatric and neurological disorders. The investigation of such possibilities is critically dependent on the availability of chemical tools that specifically modulate the activity of different PDE isoforms and have pharmacological properties amenable to different modes of delivery in experimental systems. Furthermore, in the case of the study of action in the CNS, it is highly desirable for such agents to readily cross the blood–brain barrier. This chapter reviews the tremendous progress that has been made over the last decade in the development of pharmacological tools to study the functions of the PDEs in the CNS." @default.
• W1535667752 created "2016-06-24" @default.
• W1535667752 creator A5019828463 @default.
• W1535667752 creator A5068840610 @default.
• W1535667752 creator A5073850347 @default.
• W1535667752 creator A5086505931 @default.
• W1535667752 date "2014-03-07" @default.
• W1535667752 modified "2023-09-23" @default.
• W1535667752 title "Pharmacological Manipulation of Cyclic Nucleotide Phosphodiesterase Signaling for The Treatment of Neurological and Psychiatric Disorders In The Brain" @default.
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