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- W1535682759 abstract "Abstract Thymic stromal lymphopoietin (TSLP) is a cytokine that binds the IL‐7‐receptor‐α chain and a unique TSLP receptor (TSLPR) chain. The role of TSLP in human B‐cell development has not been elucidated. We show that TSLPR transcripts are expressed most prominently in CD34 + cells from fetal liver and BM. In general, cell surface expression of TSLPR was low, except on a subset of multilineage‐commited progenitor cells. TSLP induced the tyrosine‐phosphorylation of STAT5 and the proliferation of multilineage‐commited progenitor cells, pro‐B cells and pre‐B cells. Compared with IL‐7, the levels of proliferation after stimulation of the B‐cell progenitors with TSLP were lower. Expression of the BCR on the cell surface of fetal cells was inversely correlated to TSLP or IL‐7 responsiveness. Pre‐B cells from fetal BM, but not fetal liver, were refractory to TSLP or IL‐7 stimulation. When employing an in vitro B‐cell differentiation culture system starting from CD34 + CD38 − multipotent HSC, IL‐7 induced a short wave of precursor cell expansion but did not result in long‐term survival of mature B cells. TSLP was capable of increasing the proportion and the absolute numbers of more mature human B cells. Overall, we provide evidence that TSLP supports human B‐cell differentiation from fetal hematopoietic progenitors." @default.
- W1535682759 created "2016-06-24" @default.
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- W1535682759 date "2010-04-01" @default.
- W1535682759 modified "2023-10-18" @default.
- W1535682759 title "Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation" @default.
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- W1535682759 doi "https://doi.org/10.1002/eji.200939419" @default.
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