FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535731605> ?p ?o ?g. }

• W1535731605 endingPage "186" @default.
• W1535731605 startingPage "177" @default.
• W1535731605 abstract "Background: systemic lupus erythematosus (SLE) patients have higher rates of morbility and mortality than general population because of inflammatory activity and high infections frequencies. The infections have been associated with activity index of the disease and the use of immunosuppressant drugs. Objective: to determine the factors associated with nosocomial infections in SLE patients who required in hospital treatment. Methods: we performed a prospective study of SLE patients who met the ACR criteria and who were hospitalized between January 2001 and December 2004. Exclusion criteria were community acquired infections, onset of infections in the first 48 hours of hospitalization, HIV and patients with neoplasm. The SLE activity was quantified with the SLEDAI index and infection was defined according to microorganism isolated or CDC criteria for those without an isolated microorganism. We studied this variables: age, sex, time from onset of SLE, hospital stay, use of immunosuppressant drugs, type of infection, and cause of death. Results: one hundred and twenty three patients were included who had 155 hospital admissions, 106 were women (82.2%). Mean age was 27.7 +/- 12.6 years (7-73) with a mean time from diagnostic of 27.8 +/- 49.4 months (0-300), 56 patients (45.5%) had novo diagnosis, 25 patients had chronic renal insufficiency including 10 in hemodialysis. Respect of previous treatment, 58 (47.1%) patients did not have received steroids, 36 (29.3%) have been receiving 20 mg of prednisone or less, and 29 (23.6%) more than 20 mg of prednisone, 31 (25.2%) patients pulses of ciclophosphamide and 13 others immunosuppressant drugs. The SLEDAI median and mean were 14 (IQR 7-20) and 14.7 +/- 9.9 respectively. Nosocomial infection was reported in 38 (30.9%), 31 patients just one episode of infection and 13 more than one, with a total of 69 events. In univariate analysis was noted that these factors were associated with nosocomial infections: de novo diagnosis, longer hospital stays, use of methylprednisone pulses in hospital or ciclophosphamide, SLEDAI index. In multivariate logistic regression persisted significant factors such as: longer hospital stay [OR= 5.16; (IC 95% 1.5-18) p= 0.01], use of methylprednisone [OR 3.95; (IC 95% 1.22-12.8) p= 0.02], SLEDAI index [OR 4.43; (IC 95% 1.16-16.8) p=0.03], chronic renal insuffiency [OR 5.44; (IC 95% 1.19-24.7) p= 0.03] and 20 mg or less of prednisone [OR 0.16; (IC 95% 0.03-0.95) p= 0.04]. The microorganism was isolated in 81.2% (56 events): baciles gram negative 49.3% (34), coccos gram positives 26.1% (28), fungi, hemoparasites and virus in 14.5% (10). The infections was documented from genitourinary tract in 37.7% (26), blood stream 26.1% (18), respiratory tract 11.6% (8), etc. Fourteen patients died, six from uncontrolled infections, two for activity illness, one for both infections and illness activity, three from cardiovascular causes and one unknown. Conclusion: in our SLE Colombian population almost one third of the patients had nosocomial infections that could be severe and cause major mortality. The infections were associated with higher activity of the illness, pulses of methylprednisone, chronic renal insufficiency and longer hospitalized stay." @default.
• W1535731605 created "2016-06-24" @default.
• W1535731605 creator A5000025726 @default.
• W1535731605 creator A5006450167 @default.
• W1535731605 creator A5012419801 @default.
• W1535731605 creator A5072183304 @default.
• W1535731605 creator A5085063744 @default.
• W1535731605 date "2007-01-09" @default.
• W1535731605 modified "2023-09-26" @default.
• W1535731605 title "Asociación de actividad lúpica y el riesgo de infección nosocomial en pacientes de un Hospital universitario en Medellín: estudio prospectivo 2001-2004" @default.
• W1535731605 cites W106396499 @default.
• W1535731605 cites W111481403 @default.
• W1535731605 cites W183152575 @default.
• W1535731605 cites W1963563713 @default.
• W1535731605 cites W1964041843 @default.
• W1535731605 cites W1965683411 @default.
• W1535731605 cites W1967969088 @default.
• W1535731605 cites W1974156856 @default.
• W1535731605 cites W1975347539 @default.
• W1535731605 cites W1979095334 @default.
• W1535731605 cites W1981610922 @default.
• W1535731605 cites W1986218137 @default.
• W1535731605 cites W2036058749 @default.
• W1535731605 cites W2053085401 @default.
• W1535731605 cites W2065827064 @default.
• W1535731605 cites W2070527591 @default.
• W1535731605 cites W2088340307 @default.
• W1535731605 cites W2113444295 @default.
• W1535731605 cites W2121586011 @default.
• W1535731605 cites W2132330591 @default.
• W1535731605 cites W2141975906 @default.
• W1535731605 cites W2146203649 @default.
• W1535731605 cites W2155957466 @default.
• W1535731605 cites W2246585239 @default.
• W1535731605 cites W2315955202 @default.
• W1535731605 cites W2373805913 @default.
• W1535731605 cites W2402357652 @default.
• W1535731605 cites W2431566236 @default.
• W1535731605 cites W2464185315 @default.
• W1535731605 cites W2418677597 @default.
• W1535731605 hasPublicationYear "2007" @default.
• W1535731605 type Work @default.
• W1535731605 sameAs 1535731605 @default.
• W1535731605 citedByCount "3" @default.
• W1535731605 countsByYear W15357316052015 @default.
• W1535731605 crossrefType "journal-article" @default.
• W1535731605 hasAuthorship W1535731605A5000025726 @default.
• W1535731605 hasAuthorship W1535731605A5006450167 @default.
• W1535731605 hasAuthorship W1535731605A5012419801 @default.
• W1535731605 hasAuthorship W1535731605A5072183304 @default.
• W1535731605 hasAuthorship W1535731605A5085063744 @default.
• W1535731605 hasConcept C126322002 @default.
• W1535731605 hasConcept C188816634 @default.
• W1535731605 hasConcept C2778063415 @default.
• W1535731605 hasConcept C2778720950 @default.
• W1535731605 hasConcept C2908647359 @default.
• W1535731605 hasConcept C71924100 @default.
• W1535731605 hasConcept C99454951 @default.
• W1535731605 hasConceptScore W1535731605C126322002 @default.
• W1535731605 hasConceptScore W1535731605C188816634 @default.
• W1535731605 hasConceptScore W1535731605C2778063415 @default.
• W1535731605 hasConceptScore W1535731605C2778720950 @default.
• W1535731605 hasConceptScore W1535731605C2908647359 @default.
• W1535731605 hasConceptScore W1535731605C71924100 @default.
• W1535731605 hasConceptScore W1535731605C99454951 @default.
• W1535731605 hasIssue "3" @default.
• W1535731605 hasLocation W15357316051 @default.
• W1535731605 hasOpenAccess W1535731605 @default.
• W1535731605 hasPrimaryLocation W15357316051 @default.
• W1535731605 hasRelatedWork W2100317664 @default.
• W1535731605 hasVolume "14" @default.
• W1535731605 isParatext "false" @default.
• W1535731605 isRetracted "false" @default.
• W1535731605 magId "1535731605" @default.
• W1535731605 workType "article" @default.