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- W1535815434 abstract "For over two decades now, the recombinant form of erythropoietin (RhEPO) is used for the treatment of anemia in end-stage renal disease patients. Initial studies indicated an improvement in quality of life [1]. However, neutral/ negative data from two randomized controlled trials testing RhEPO to correct anemia in chronic kidney disease (CKD) were recently reported [2, 3]. The CHOIR study evaluated the effects of achieving high Hb levels (13.5 g/dl) compared to lower Hb levels (11.3 g/dl) on cardiovascular complications in CKD patients with an eGFR ≤50 ml/min/ 1.73 m 2 . This study was prematurely halted, because of an increased adverse event rate in the high Hb group [2]. The CREATE study evaluated the effect of complete Hb correction (13.0 to 15.0 g/dl) to lower hemoglobin (Hb) correction (10.5–11.5 g/dl) in CKD patients with an eGFR <35 ml/min/1.73 m 2 . In these patients complete correction" @default.
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- W1535815434 date "2008-01-25" @default.
- W1535815434 modified "2023-09-27" @default.
- W1535815434 title "Recombinant Human Epo Treatment: Beneficial in Chronic Kidney Disease, Chronic Heart Failure, or Both?" @default.
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- W1535815434 doi "https://doi.org/10.1007/s10557-008-6079-x" @default.
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