Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535859471> ?p ?o ?g. }
- W1535859471 endingPage "228" @default.
- W1535859471 startingPage "216" @default.
- W1535859471 abstract "Summary Candida albicans is more pathogenic than Candida dubliniensis . However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two species. Increased sensitivity to environmental stresses has been suggested to be a possible contributory factor to the lower virulence of C. dubliniensis . In this study, we investigated, in the first comparison of C. albicans and C. dubliniensis by transcriptional profiling, global gene expression in each species when grown under conditions in which the two species exhibit differential stress tolerance. The profiles revealed similar core responses to stresses in both species, but differences in the amplitude of the general transcriptional responses to thermal, salt and oxidative stress. Differences in the regulation of specific stress genes were observed between the two species. In particular, ENA21 , encoding a sodium ion transporter, was strongly induced in C. albicans but not in C. dubliniensis . In addition, ENA21 was identified in a forward genetic screen for C. albicans genomic sequences that increase salt tolerance in C. dubliniensis . Introduction of a single copy of CaENA21 was subsequently shown to be sufficient to confer salt tolerance upon C. dubliniensis ." @default.
- W1535859471 created "2016-06-24" @default.
- W1535859471 creator A5014257873 @default.
- W1535859471 creator A5019826825 @default.
- W1535859471 creator A5056012034 @default.
- W1535859471 creator A5058277394 @default.
- W1535859471 creator A5062854948 @default.
- W1535859471 creator A5067712083 @default.
- W1535859471 creator A5072811112 @default.
- W1535859471 creator A5082487781 @default.
- W1535859471 creator A5088189848 @default.
- W1535859471 date "2009-03-19" @default.
- W1535859471 modified "2023-10-16" @default.
- W1535859471 title "Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress" @default.
- W1535859471 cites W1517616366 @default.
- W1535859471 cites W1648076724 @default.
- W1535859471 cites W1970205165 @default.
- W1535859471 cites W1974063203 @default.
- W1535859471 cites W1978684735 @default.
- W1535859471 cites W1980787512 @default.
- W1535859471 cites W1993124594 @default.
- W1535859471 cites W2002955084 @default.
- W1535859471 cites W2017887007 @default.
- W1535859471 cites W2030202942 @default.
- W1535859471 cites W2034303449 @default.
- W1535859471 cites W2045720766 @default.
- W1535859471 cites W2060721894 @default.
- W1535859471 cites W2082335793 @default.
- W1535859471 cites W2084799249 @default.
- W1535859471 cites W2096060313 @default.
- W1535859471 cites W2103682285 @default.
- W1535859471 cites W2104880204 @default.
- W1535859471 cites W2110874942 @default.
- W1535859471 cites W2125153461 @default.
- W1535859471 cites W2126357275 @default.
- W1535859471 cites W2127851875 @default.
- W1535859471 cites W2130346789 @default.
- W1535859471 cites W2131037746 @default.
- W1535859471 cites W2133572247 @default.
- W1535859471 cites W2134809769 @default.
- W1535859471 cites W2134909835 @default.
- W1535859471 cites W2137683543 @default.
- W1535859471 cites W2144236385 @default.
- W1535859471 cites W2145692134 @default.
- W1535859471 cites W2146225432 @default.
- W1535859471 cites W2149118697 @default.
- W1535859471 cites W2151797788 @default.
- W1535859471 cites W2153104382 @default.
- W1535859471 cites W2165403985 @default.
- W1535859471 cites W2166379323 @default.
- W1535859471 cites W2167498848 @default.
- W1535859471 cites W2170040727 @default.
- W1535859471 cites W4240065971 @default.
- W1535859471 cites W4294107304 @default.
- W1535859471 doi "https://doi.org/10.1111/j.1365-2958.2009.06640.x" @default.
- W1535859471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19239621" @default.
- W1535859471 hasPublicationYear "2009" @default.
- W1535859471 type Work @default.
- W1535859471 sameAs 1535859471 @default.
- W1535859471 citedByCount "38" @default.
- W1535859471 countsByYear W15358594712012 @default.
- W1535859471 countsByYear W15358594712013 @default.
- W1535859471 countsByYear W15358594712014 @default.
- W1535859471 countsByYear W15358594712015 @default.
- W1535859471 countsByYear W15358594712016 @default.
- W1535859471 countsByYear W15358594712017 @default.
- W1535859471 countsByYear W15358594712018 @default.
- W1535859471 countsByYear W15358594712020 @default.
- W1535859471 countsByYear W15358594712021 @default.
- W1535859471 countsByYear W15358594712022 @default.
- W1535859471 countsByYear W15358594712023 @default.
- W1535859471 crossrefType "journal-article" @default.
- W1535859471 hasAuthorship W1535859471A5014257873 @default.
- W1535859471 hasAuthorship W1535859471A5019826825 @default.
- W1535859471 hasAuthorship W1535859471A5056012034 @default.
- W1535859471 hasAuthorship W1535859471A5058277394 @default.
- W1535859471 hasAuthorship W1535859471A5062854948 @default.
- W1535859471 hasAuthorship W1535859471A5067712083 @default.
- W1535859471 hasAuthorship W1535859471A5072811112 @default.
- W1535859471 hasAuthorship W1535859471A5082487781 @default.
- W1535859471 hasAuthorship W1535859471A5088189848 @default.
- W1535859471 hasBestOaLocation W15358594711 @default.
- W1535859471 hasConcept C104317684 @default.
- W1535859471 hasConcept C127716648 @default.
- W1535859471 hasConcept C145081991 @default.
- W1535859471 hasConcept C150194340 @default.
- W1535859471 hasConcept C2776445003 @default.
- W1535859471 hasConcept C2780917455 @default.
- W1535859471 hasConcept C54355233 @default.
- W1535859471 hasConcept C60987743 @default.
- W1535859471 hasConcept C86803240 @default.
- W1535859471 hasConceptScore W1535859471C104317684 @default.
- W1535859471 hasConceptScore W1535859471C127716648 @default.
- W1535859471 hasConceptScore W1535859471C145081991 @default.
- W1535859471 hasConceptScore W1535859471C150194340 @default.
- W1535859471 hasConceptScore W1535859471C2776445003 @default.
- W1535859471 hasConceptScore W1535859471C2780917455 @default.
- W1535859471 hasConceptScore W1535859471C54355233 @default.