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• W1535911598 startingPage "6673" @default.
• W1535911598 abstract "To examine the different roles of myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) in the induction and regulation of immune response, we have studied chemokine secretion by freshly isolated DC subsets in response to bacterial, viral, and T cell-derived stimuli. M-DCs selectively produced very high levels of the homeostatic chemokines CC chemokine ligand (CCL)17 and CCL22, while P-DCs produced very little if any. In contrast, the proinflammatory chemokine CCL3 was secreted mostly by P-DCs, whereas CCL4 and CXC chemokine ligand 8 were produced by both subsets. The selective production of CCL17 and CCL22 by M-DCs but not P-DCs was confirmed in vivo by immunohistology on human reactive lymph node sections. The high production of CCR4 ligands by M-DCs suggests their capacity to selectively recruit at sites of inflammation T cells with regulatory properties or with a Th2 phenotype, whereas P-DCs, by preferentially secreting CCR1/CCR5 ligands, would mostly recruit effector T cells and, in particular, Th1-type cells." @default.
• W1535911598 created "2016-06-24" @default.
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• W1535911598 date "2002-12-15" @default.
• W1535911598 modified "2023-09-26" @default.
• W1535911598 title "Cutting Edge: Differential Chemokine Production by Myeloid and Plasmacytoid Dendritic Cells" @default.
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• W1535911598 doi "https://doi.org/10.4049/jimmunol.169.12.6673" @default.
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