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• W1535966479 abstract "ABSTRACT Over the last 30 years, epidemiological studies have shown that COPD is the single most important risk factor for lung cancer after smoking exposure. Recent genetic studies using genome‐wide approaches suggest that the genetic risk factors predisposing smokers to COPD and lung cancer may overlap. The genes identified by these studies suggest that this overlapping genetic susceptibility may be mediated through receptors expressed on the bronchial epithelium that implicate molecular pathways underlying both COPD and lung cancer. Furthermore, it appears that aberrant inflammatory and/or immune‐modulatory pathways leading to excess matrix metalloproteinases, growth factors and airway remodelling in COPD may also be promoting malignant transformation of the bronchial epithelium. The process linking inflammation, remodelling and cancer formation is called epithelial‐mesenchymal transition. There are several clinical implications arising from the COPD–lung cancer overlap. First, if COPD is a precursor disease to lung cancer then efforts to prevent COPD, might be even more important. Second, if drugs targeting the overlapping molecular pathways can be identified, chemoprevention that reduce the propensity to COPD and lung cancer is an attractive option. Finally, if low‐dose computerized tomography can identify treatable lung cancer, gene‐based tests of susceptibility might help identify those smokers who should undergo radiological screening." @default.
• W1535966479 created "2016-06-24" @default.
• W1535966479 creator A5004622383 @default.
• W1535966479 creator A5032885485 @default.
• W1535966479 date "2011-09-26" @default.
• W1535966479 modified "2023-10-16" @default.
• W1535966479 title "How the genetics of lung cancer may overlap with COPD" @default.
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• W1535966479 cites W1963612032 @default.
• W1535966479 cites W1964185212 @default.
• W1535966479 cites W1964478846 @default.
• W1535966479 cites W1969574651 @default.
• W1535966479 cites W1971000546 @default.
• W1535966479 cites W1971018030 @default.
• W1535966479 cites W1971501057 @default.
• W1535966479 cites W1972020976 @default.
• W1535966479 cites W1977273234 @default.
• W1535966479 cites W1979581505 @default.
• W1535966479 cites W1980008048 @default.
• W1535966479 cites W1986672886 @default.
• W1535966479 cites W2002818848 @default.
• W1535966479 cites W2002955275 @default.
• W1535966479 cites W2006720016 @default.
• W1535966479 cites W2016927771 @default.
• W1535966479 cites W2019249554 @default.
• W1535966479 cites W2021085462 @default.
• W1535966479 cites W2024625151 @default.
• W1535966479 cites W2032580948 @default.
• W1535966479 cites W2038206806 @default.
• W1535966479 cites W2044016511 @default.
• W1535966479 cites W2055296003 @default.
• W1535966479 cites W2063159152 @default.
• W1535966479 cites W2064786372 @default.
• W1535966479 cites W2066422496 @default.
• W1535966479 cites W2068727310 @default.
• W1535966479 cites W2075040668 @default.
• W1535966479 cites W2077030176 @default.
• W1535966479 cites W2084243189 @default.
• W1535966479 cites W2085153747 @default.
• W1535966479 cites W2089415609 @default.
• W1535966479 cites W2089703171 @default.
• W1535966479 cites W2093921175 @default.
• W1535966479 cites W2097663271 @default.
• W1535966479 cites W2102417402 @default.
• W1535966479 cites W2103809903 @default.
• W1535966479 cites W2103821820 @default.
• W1535966479 cites W2105510147 @default.
• W1535966479 cites W2105843214 @default.
• W1535966479 cites W2107766358 @default.
• W1535966479 cites W2110573194 @default.
• W1535966479 cites W2111344085 @default.
• W1535966479 cites W2111591597 @default.
• W1535966479 cites W2112495658 @default.
• W1535966479 cites W2115485344 @default.
• W1535966479 cites W2116141140 @default.
• W1535966479 cites W2118082971 @default.
• W1535966479 cites W2119037301 @default.
• W1535966479 cites W2119089168 @default.
• W1535966479 cites W2119729352 @default.
• W1535966479 cites W2120240963 @default.
• W1535966479 cites W2120332982 @default.
• W1535966479 cites W2120902800 @default.
• W1535966479 cites W2123600689 @default.
• W1535966479 cites W2125063678 @default.
• W1535966479 cites W2128180660 @default.
• W1535966479 cites W2129183735 @default.
• W1535966479 cites W2132297922 @default.
• W1535966479 cites W2132869277 @default.
• W1535966479 cites W2133461233 @default.
• W1535966479 cites W2136737511 @default.
• W1535966479 cites W2137397912 @default.
• W1535966479 cites W2137674326 @default.
• W1535966479 cites W2138958247 @default.
• W1535966479 cites W2139697423 @default.
• W1535966479 cites W2146533975 @default.
• W1535966479 cites W2148263031 @default.
• W1535966479 cites W2150472441 @default.
• W1535966479 cites W2151692695 @default.
• W1535966479 cites W2151941056 @default.
• W1535966479 cites W2154208846 @default.
• W1535966479 cites W2154589460 @default.
• W1535966479 cites W2157229563 @default.
• W1535966479 cites W2157409103 @default.
• W1535966479 cites W2160762156 @default.
• W1535966479 cites W2163813420 @default.
• W1535966479 cites W2165405205 @default.
• W1535966479 cites W2166406579 @default.
• W1535966479 cites W2167405133 @default.
• W1535966479 cites W2169237347 @default.
• W1535966479 cites W2169973391 @default.
• W1535966479 cites W2185440705 @default.
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• W1535966479 doi "https://doi.org/10.1111/j.1440-1843.2011.02019.x" @default.
• W1535966479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21749550" @default.
• W1535966479 hasPublicationYear "2011" @default.
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