Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536005089> ?p ?o ?g. }
- W1536005089 endingPage "68" @default.
- W1536005089 startingPage "1357" @default.
- W1536005089 abstract "Activation of the complement (C) system has been documented in both experimental and clinical studies of myocardial infarction, but the exact time course and mechanisms leading to C activation have remained unclear. Our earlier postmortem study on human beings showed that formation of the membrane attack complex (MAC) of C was associated with loss of CD59 (protectin), an important sarcolemmal regulator of MAC, from the infarcted area. The recent discovery of a rat analogue of CD59 has now allowed the first experimental evaluation of the temporal and spatial relationship between C component deposition and loss of CD59 in acute myocardial infarction (AMI). After ligating the left coronary artery in rats the earliest sign of C activation, focal deposition of C3, was observed at 2 hours. Deposition of the early (C1, C3) and late pathway (C8, C9) components in the AMI lesions occurred at 3 hours. Glycophosphoinositol-anchored rat CD59 was expressed in the sarcolemmal membranes of normal cardiomyocytes. In Western blot analysis extracts of normal rat heart CD59 appeared as a band of 21 kd of molecular weight under nonreducing conditions. Loss of CD59 in the AMI lesions was observed in association with deposits of MAC from day one onward. Our results show that C activation universally accompanies AMI in vivo. It is initiated within 2 hours after coronary artery obstruction via deposition of C3, which may be due to generation of the alternative pathway C3 convertase in the ischemic area. Deposition of C1 and late C components also starts during the early hours (2 to 4 hours) after ischemia. Subsequent loss of the protective CD59 antigen may initiate postinjury clearance of the irreversibly damaged tissue." @default.
- W1536005089 created "2016-06-24" @default.
- W1536005089 creator A5004757942 @default.
- W1536005089 creator A5011822969 @default.
- W1536005089 creator A5023246337 @default.
- W1536005089 creator A5025820462 @default.
- W1536005089 creator A5069035614 @default.
- W1536005089 creator A5091436961 @default.
- W1536005089 date "1994-06-01" @default.
- W1536005089 modified "2023-10-03" @default.
- W1536005089 title "Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium." @default.
- W1536005089 cites W1481229608 @default.
- W1536005089 cites W149526388 @default.
- W1536005089 cites W1549348777 @default.
- W1536005089 cites W1563729327 @default.
- W1536005089 cites W1600368065 @default.
- W1536005089 cites W1638095527 @default.
- W1536005089 cites W1643681311 @default.
- W1536005089 cites W168399381 @default.
- W1536005089 cites W1726093383 @default.
- W1536005089 cites W1828340002 @default.
- W1536005089 cites W1922947289 @default.
- W1536005089 cites W1979008403 @default.
- W1536005089 cites W1995765455 @default.
- W1536005089 cites W1998713304 @default.
- W1536005089 cites W2001664656 @default.
- W1536005089 cites W2018289835 @default.
- W1536005089 cites W2024282635 @default.
- W1536005089 cites W2033827361 @default.
- W1536005089 cites W2038613484 @default.
- W1536005089 cites W2044856099 @default.
- W1536005089 cites W2047951734 @default.
- W1536005089 cites W2066092834 @default.
- W1536005089 cites W2071177681 @default.
- W1536005089 cites W2083708523 @default.
- W1536005089 cites W2094086361 @default.
- W1536005089 cites W2100837269 @default.
- W1536005089 cites W2127290864 @default.
- W1536005089 cites W2129822724 @default.
- W1536005089 cites W2133318613 @default.
- W1536005089 cites W2152506674 @default.
- W1536005089 cites W2168792260 @default.
- W1536005089 cites W2177078605 @default.
- W1536005089 cites W2398655886 @default.
- W1536005089 cites W2405624078 @default.
- W1536005089 cites W2413683471 @default.
- W1536005089 cites W66923790 @default.
- W1536005089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887457" @default.
- W1536005089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7515561" @default.
- W1536005089 hasPublicationYear "1994" @default.
- W1536005089 type Work @default.
- W1536005089 sameAs 1536005089 @default.
- W1536005089 citedByCount "42" @default.
- W1536005089 countsByYear W15360050892012 @default.
- W1536005089 countsByYear W15360050892013 @default.
- W1536005089 countsByYear W15360050892015 @default.
- W1536005089 countsByYear W15360050892016 @default.
- W1536005089 countsByYear W15360050892017 @default.
- W1536005089 countsByYear W15360050892018 @default.
- W1536005089 countsByYear W15360050892019 @default.
- W1536005089 countsByYear W15360050892020 @default.
- W1536005089 countsByYear W15360050892021 @default.
- W1536005089 crossrefType "journal-article" @default.
- W1536005089 hasAuthorship W1536005089A5004757942 @default.
- W1536005089 hasAuthorship W1536005089A5011822969 @default.
- W1536005089 hasAuthorship W1536005089A5023246337 @default.
- W1536005089 hasAuthorship W1536005089A5025820462 @default.
- W1536005089 hasAuthorship W1536005089A5069035614 @default.
- W1536005089 hasAuthorship W1536005089A5091436961 @default.
- W1536005089 hasConcept C111684460 @default.
- W1536005089 hasConcept C126322002 @default.
- W1536005089 hasConcept C142724271 @default.
- W1536005089 hasConcept C150903083 @default.
- W1536005089 hasConcept C164705383 @default.
- W1536005089 hasConcept C184404459 @default.
- W1536005089 hasConcept C185592680 @default.
- W1536005089 hasConcept C189446657 @default.
- W1536005089 hasConcept C203014093 @default.
- W1536005089 hasConcept C207001950 @default.
- W1536005089 hasConcept C2776820930 @default.
- W1536005089 hasConcept C500558357 @default.
- W1536005089 hasConcept C541997718 @default.
- W1536005089 hasConcept C71924100 @default.
- W1536005089 hasConcept C79196540 @default.
- W1536005089 hasConcept C86803240 @default.
- W1536005089 hasConcept C8891405 @default.
- W1536005089 hasConcept C9478725 @default.
- W1536005089 hasConceptScore W1536005089C111684460 @default.
- W1536005089 hasConceptScore W1536005089C126322002 @default.
- W1536005089 hasConceptScore W1536005089C142724271 @default.
- W1536005089 hasConceptScore W1536005089C150903083 @default.
- W1536005089 hasConceptScore W1536005089C164705383 @default.
- W1536005089 hasConceptScore W1536005089C184404459 @default.
- W1536005089 hasConceptScore W1536005089C185592680 @default.
- W1536005089 hasConceptScore W1536005089C189446657 @default.
- W1536005089 hasConceptScore W1536005089C203014093 @default.
- W1536005089 hasConceptScore W1536005089C207001950 @default.
- W1536005089 hasConceptScore W1536005089C2776820930 @default.