FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536005161> ?p ?o ?g. }

• W1536005161 endingPage "7" @default.
• W1536005161 startingPage "1" @default.
• W1536005161 abstract "The field of genetic epidemiology seeks to identify the genetic risk factors underlying human disease. First, one must assess whether the trait has an underlying genetic influence, by estimating familial relative risk and/or conducting segregation analysis. In order to discover genes influencing human disease, both family- and population-based studies are designed, and linkage and association methods are used to analyse the relationship between the trait(s) of interest and genetic markers. In general, linkage analysis is more powerful for detecting rare genes with large effects, whereas association analysis is more powerful for detecting common alleles with smaller effects. For the genetics of complex traits, additional factors must be considered, including rare variants, interactions with other genes and the environment, parent-of-origin effects and structural variants. Finally, casualty needs to be established beyond statistical implication of association with disease. Key Concepts Genetic epidemiologists design both family- and population-based studies to find genes influencing disease risk. Before conducting a gene-mapping study, one must first ascertain whether the trait is influenced by genetic effects. Linkage and association analysis are two complementary methods used to analyse the relationship between trait(s) and genetic markers. The approach used (linkage vs association) depends on the study design, and these approaches depend on the genetic parameters (rare vs common alleles and large vs small effects). Other factors – rare variants, gene–gene and gene–environment interaction, existence of structural variants and parent-of-origin effects – further complicate the search for disease genes." @default.
• W1536005161 created "2016-06-24" @default.
• W1536005161 creator A5041230435 @default.
• W1536005161 creator A5051524591 @default.
• W1536005161 creator A5057370516 @default.
• W1536005161 date "2016-11-03" @default.
• W1536005161 modified "2023-10-16" @default.
• W1536005161 title "Identifying Genes Underlying Human Inherited Disease" @default.
• W1536005161 cites W1484286881 @default.
• W1536005161 cites W1507312197 @default.
• W1536005161 cites W1554372034 @default.
• W1536005161 cites W1903712632 @default.
• W1536005161 cites W1965193360 @default.
• W1536005161 cites W1966938977 @default.
• W1536005161 cites W1968882959 @default.
• W1536005161 cites W1977308882 @default.
• W1536005161 cites W1978150238 @default.
• W1536005161 cites W1980991473 @default.
• W1536005161 cites W1981373635 @default.
• W1536005161 cites W1982733535 @default.
• W1536005161 cites W1990139289 @default.
• W1536005161 cites W1998641738 @default.
• W1536005161 cites W2007203150 @default.
• W1536005161 cites W2007988561 @default.
• W1536005161 cites W2008047653 @default.
• W1536005161 cites W2018536355 @default.
• W1536005161 cites W2021753580 @default.
• W1536005161 cites W2028857929 @default.
• W1536005161 cites W2038635666 @default.
• W1536005161 cites W2041467022 @default.
• W1536005161 cites W2042909973 @default.
• W1536005161 cites W2046247026 @default.
• W1536005161 cites W2047361940 @default.
• W1536005161 cites W2047550265 @default.
• W1536005161 cites W2050897245 @default.
• W1536005161 cites W2057012029 @default.
• W1536005161 cites W2068718302 @default.
• W1536005161 cites W2087875300 @default.
• W1536005161 cites W2096285420 @default.
• W1536005161 cites W2098126593 @default.
• W1536005161 cites W2099527353 @default.
• W1536005161 cites W2100980426 @default.
• W1536005161 cites W2102697854 @default.
• W1536005161 cites W2104549677 @default.
• W1536005161 cites W2106036991 @default.
• W1536005161 cites W2107063140 @default.
• W1536005161 cites W2110343195 @default.
• W1536005161 cites W2123466824 @default.
• W1536005161 cites W2129465958 @default.
• W1536005161 cites W2131104106 @default.
• W1536005161 cites W2134783591 @default.
• W1536005161 cites W2136078375 @default.
• W1536005161 cites W2143142289 @default.
• W1536005161 cites W2143992683 @default.
• W1536005161 cites W2150497848 @default.
• W1536005161 cites W2152664025 @default.
• W1536005161 cites W2153622221 @default.
• W1536005161 cites W2170801877 @default.
• W1536005161 cites W2217809488 @default.
• W1536005161 cites W4319590830 @default.
• W1536005161 doi "https://doi.org/10.1002/9780470015902.a0022395.pub2" @default.
• W1536005161 hasPublicationYear "2016" @default.
• W1536005161 type Work @default.
• W1536005161 sameAs 1536005161 @default.
• W1536005161 citedByCount "1" @default.
• W1536005161 countsByYear W15360051612012 @default.
• W1536005161 crossrefType "other" @default.
• W1536005161 hasAuthorship W1536005161A5041230435 @default.
• W1536005161 hasAuthorship W1536005161A5051524591 @default.
• W1536005161 hasAuthorship W1536005161A5057370516 @default.
• W1536005161 hasConcept C104317684 @default.
• W1536005161 hasConcept C106934330 @default.
• W1536005161 hasConcept C135763542 @default.
• W1536005161 hasConcept C142724271 @default.
• W1536005161 hasConcept C142870003 @default.
• W1536005161 hasConcept C153209595 @default.
• W1536005161 hasConcept C180754005 @default.
• W1536005161 hasConcept C186413461 @default.
• W1536005161 hasConcept C199360897 @default.
• W1536005161 hasConcept C2779134260 @default.
• W1536005161 hasConcept C2908647359 @default.
• W1536005161 hasConcept C31266012 @default.
• W1536005161 hasConcept C41008148 @default.
• W1536005161 hasConcept C54355233 @default.
• W1536005161 hasConcept C69991583 @default.
• W1536005161 hasConcept C71924100 @default.
• W1536005161 hasConcept C78458016 @default.
• W1536005161 hasConcept C81941488 @default.
• W1536005161 hasConcept C86803240 @default.
• W1536005161 hasConcept C99454951 @default.
• W1536005161 hasConceptScore W1536005161C104317684 @default.
• W1536005161 hasConceptScore W1536005161C106934330 @default.
• W1536005161 hasConceptScore W1536005161C135763542 @default.
• W1536005161 hasConceptScore W1536005161C142724271 @default.
• W1536005161 hasConceptScore W1536005161C142870003 @default.
• W1536005161 hasConceptScore W1536005161C153209595 @default.
• W1536005161 hasConceptScore W1536005161C180754005 @default.
• W1536005161 hasConceptScore W1536005161C186413461 @default.

• next