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- W1536052010 abstract "Purpose Diffusion magnetic resonance imaging (MRI) microstructure imaging provides a unique noninvasive probe into tissue microstructure. The technique relies on biophysically motivated mathematical models, relating microscopic tissue features to the magnetic resonance (MR) signal. This work aims to determine which compartment models of diffusion MRI are best at describing measurements from in vivo human brain white matter. Methods Recent work shows that three compartment models, designed to capture intra‐axonal, extracellular, and isotropically restricted diffusion, best explain multi‐ b ‐value data sets from fixed rat corpus callosum. We extend this investigation to in vivo by using a live human subject on a clinical scanner. The analysis compares models of one, two, and three compartments and ranks their ability to explain the measured data. We enhance the original methodology to further evaluate the stability of the ranking. Results As with fixed tissue, three compartment models explain the data best. However, a clearer hierarchical structure and simpler models emerge. We also find that splitting the scanning into shorter sessions has little effect on the ranking of models, and that the results are broadly reproducible across sessions. Conclusion Three compartments are required to explain diffusion MR measurements from in vivo corpus callosum, which informs the choice of model for microstructure imaging applications in the brain. Magn Reson Med 72:1785–1792, 2014. © 2013 The authors. Magnetic Resonance in Medicine Published by Wiley Periodicals, Inc. on behalf of International Society of Medicine in Resonance." @default.
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- W1536052010 date "2013-12-17" @default.
- W1536052010 modified "2023-10-05" @default.
- W1536052010 title "A ranking of diffusion MRI compartment models with in vivo human brain data" @default.
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- W1536052010 doi "https://doi.org/10.1002/mrm.25080" @default.
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