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- W1536275272 abstract "The translational machinery of mammalian cells is regulated through the phosphorylation of a number of its components, especially translation factor proteins. These include factors involved in the initiation and elongation stages of translation, and proteins that modify their activity. Examples include eukaryotic initiation factor (eIF) 4E, eukaryotic elongation factor (eEF) 2, and eIF4E-binding protein 1 (4E-BP1). Their phosphorylation is mediated by protein kinases that, in turn, are regulated by specific intracellular signaling pathways. These pathways include those mediated via the mammalian target of rapamycin (mTOR), the ERK and p38 MAP kinase pathways, and protein kinase B (Akt). These pathways are activated by hormones (e.g., insulin), growth factors, mitogens, and other extracellular stimuli. In some cases, amino acids also modulate the pathway (e.g., mTOR). Procedures are described for determining the states of phosphorylation and/or activity of several translation factors, and of kinases that phosphorylate them. We also outline procedures for assessing the states of activation of relevant signaling pathways. In addition, we provide guidelines on using small molecule inhibitors to assess the involvement of specific signaling pathways in controlling translation factors and protein synthesis." @default.
- W1536275272 created "2016-06-24" @default.
- W1536275272 creator A5000032814 @default.
- W1536275272 creator A5030513468 @default.
- W1536275272 date "2007-01-01" @default.
- W1536275272 modified "2023-09-23" @default.
- W1536275272 title "Methods for Studying Signal‐Dependent Regulation of Translation Factor Activity" @default.
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- W1536275272 cites W1689754237 @default.
- W1536275272 cites W1797700808 @default.
- W1536275272 cites W1818313483 @default.
- W1536275272 cites W1855397569 @default.
- W1536275272 cites W1969388212 @default.
- W1536275272 cites W1971357899 @default.
- W1536275272 cites W1971915141 @default.
- W1536275272 cites W1983698019 @default.
- W1536275272 cites W1988758124 @default.
- W1536275272 cites W1991738330 @default.
- W1536275272 cites W1993628564 @default.
- W1536275272 cites W1993974348 @default.
- W1536275272 cites W1997191108 @default.
- W1536275272 cites W1998485425 @default.
- W1536275272 cites W1998682097 @default.
- W1536275272 cites W1998709616 @default.
- W1536275272 cites W2011026076 @default.
- W1536275272 cites W2011588737 @default.
- W1536275272 cites W2012440244 @default.
- W1536275272 cites W2015674575 @default.
- W1536275272 cites W2018553282 @default.
- W1536275272 cites W2019800572 @default.
- W1536275272 cites W2020151423 @default.
- W1536275272 cites W2021669986 @default.
- W1536275272 cites W2022914311 @default.
- W1536275272 cites W2024158998 @default.
- W1536275272 cites W2032666422 @default.
- W1536275272 cites W2032731042 @default.
- W1536275272 cites W2035936653 @default.
- W1536275272 cites W2042359206 @default.
- W1536275272 cites W2044693162 @default.
- W1536275272 cites W2052583546 @default.
- W1536275272 cites W2052615604 @default.
- W1536275272 cites W2052750950 @default.
- W1536275272 cites W2053112623 @default.
- W1536275272 cites W2053284114 @default.
- W1536275272 cites W2054998824 @default.
- W1536275272 cites W2057327606 @default.
- W1536275272 cites W2062801148 @default.
- W1536275272 cites W2062934426 @default.
- W1536275272 cites W2065613854 @default.
- W1536275272 cites W2077230170 @default.
- W1536275272 cites W2078142614 @default.
- W1536275272 cites W2086262311 @default.
- W1536275272 cites W2086655427 @default.
- W1536275272 cites W2089632625 @default.
- W1536275272 cites W2094853437 @default.
- W1536275272 cites W2094941511 @default.
- W1536275272 cites W2094964407 @default.
- W1536275272 cites W2099136664 @default.
- W1536275272 cites W2099389441 @default.
- W1536275272 cites W2102889876 @default.
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- W1536275272 cites W2108360575 @default.
- W1536275272 cites W2109430904 @default.
- W1536275272 cites W2112013596 @default.
- W1536275272 cites W2113288593 @default.
- W1536275272 cites W2117028091 @default.
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- W1536275272 cites W2133181350 @default.
- W1536275272 cites W2134128731 @default.
- W1536275272 cites W2134138119 @default.
- W1536275272 cites W2140254301 @default.
- W1536275272 cites W2144099695 @default.
- W1536275272 cites W2151357723 @default.
- W1536275272 cites W2152526811 @default.
- W1536275272 cites W2155905959 @default.
- W1536275272 cites W2158389310 @default.
- W1536275272 cites W2158612356 @default.
- W1536275272 cites W2164462432 @default.
- W1536275272 cites W2170242482 @default.
- W1536275272 cites W4238567307 @default.
- W1536275272 cites W4251148712 @default.
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- W1536275272 doi "https://doi.org/10.1016/s0076-6879(07)31007-0" @default.
- W1536275272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17923233" @default.
- W1536275272 hasPublicationYear "2007" @default.
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