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- W1536280314 abstract "C38 The availability of new and more effective anticancer drugs is considered to be the key for the achievement of a substantial improvement in the treatment of advanced non-small cell lung cancer (NSCLC). More hope lies in the isolation of bioactive phytochemicals from medicinal plants for their possible usefulness in the control of various ailments. Coumarins, naturally occurring benzopyrene derivatives have attracted intense interest in recent years because these have been identified from natural source, especially green plants and have diverse pharmacological activity. In the present study we examined the effect of antioxidant coumarin DAMC (7,8 Diacetoxy 4 methyl coumarin) and its thioderivative DAMTC (7,8 Diacetoxy 4 methyl thiocoumarin ) on human non small cell lung cancer A549 cells. We observed that both DAMC and DAMTC inhibit cellular proliferation in a dose dependent manner. These coumarin compounds also induce apoptosis as confirmed by annexin assay and cell cycle analysis. Induction of apoptosis occurs through mitochondrial mediated pathway as both DAMC and DAMTC caused the release of cytochrome c to the cytosol and activates caspase-9 without affecting the activity of caspase-8. Further studying the mechanism of action of these coumarin compounds we found that DAMC and DAMTC alters the expression of several genes (proapoptotic as well as antiapoptotic) as shown by western blot analysis. Our findings may offer new insight into the antiproliferative activity of DAMC and its thiocoumarin derivative DAMTC in A549 cells which will be important to fully exploit the potential of these drugs as chemotherapeutic agents." @default.
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- W1536280314 date "2007-11-15" @default.
- W1536280314 modified "2023-09-22" @default.
- W1536280314 title "Antiproliferative effects of 7,8 diacetoxy 4 methyl coumarin and 7,8 diacetoxy 4 methyl thiocoumarin in human lung adenocarcinoma cell line" @default.
- W1536280314 hasPublicationYear "2007" @default.
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