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• W1536410620 abstract "Rai (Shc C or N-Shc) is a neuron-specific member of the family of Shc-like adaptor proteins. Rai functions in the cytoplasmic propagation of Ret-dependent survival signals and regulates, in vivo , the number of sympathetic neurons. We report here a function of Rai, i.e., the regulation of the neuronal adaptive response to environmental stresses. We demonstrate that ( i ) primary cultures of cortical neurons from Rai -/- mice are more sensitive to apoptosis induced by hypoxia or oxidative stress; ( ii ) in Rai -/- mice, ischemia/reperfusion injury induces severe neurological deficits, increased apoptosis and size of the infarct area, and significantly higher mortality; and ( iii ) Rai functions as a stress-response gene that increases phosphatidylinositol 3-kinase activation and Akt phosphorylation after hypoxic or oxidation insults. These data suggest that Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke." @default.
• W1536410620 created "2016-06-24" @default.
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• W1536410620 date "2004-10-19" @default.
• W1536410620 modified "2023-09-25" @default.
• W1536410620 title "The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia" @default.
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• W1536410620 doi "https://doi.org/10.1073/pnas.0403283101" @default.
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