FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536611676> ?p ?o ?g. }

• W1536611676 endingPage "1469" @default.
• W1536611676 startingPage "1458" @default.
• W1536611676 abstract "There are varying, often conflicting, reports with respect to altered striatal volume and morphometry in the major psychoses due to the influences of antipsychotic medications on striatal volume. Thus, disassociating disease effects from those of medication become exceedingly difficult. For the first time, using a longitudinally studied sample of structural magnetic resonance images from patients with childhood onset schizophrenia (COS; neurobiologically contiguous with the adult onset form of schizophrenia), their nonpsychotic siblings (COSSIBs), and novel shape mapping algorithms that are volume independent, we report the familial contribution of striatal morphology in schizophrenia. The results of our volumetric analyses demonstrate age-related increases in overall striatal volumes specific only to COS. However, both COS and COSSIBs showed overlapping shape differences in the striatal head, which normalized in COSSIBs by late adolescence. These results mirror previous studies from our group, demonstrating cortical thickness deficits in COS and COSSIBs as these deficits normalize in COSSIBs in the same age range as our striatal findings. Finally, there is a single region of nonoverlapping outward displacement in the dorsal aspect of the caudate body, potentially indicative of a response to medication. Striatal shape may be considered complimentary to volume as an endophenotype, and, in some cases may provide information that is not detectable using standard volumetric techniques. Our striatal shape findings demonstrate the striking localization of abnormalities in striatal the head. The neuroanatomical localization of these findings suggest the presence of abnormalities in the striatal-prefrontal circuits in schizophrenia and resilience mechanisms in COSSIBs with age dependent normalization." @default.
• W1536611676 created "2016-06-24" @default.
• W1536611676 creator A5016285763 @default.
• W1536611676 creator A5016908990 @default.
• W1536611676 creator A5057781498 @default.
• W1536611676 creator A5058105019 @default.
• W1536611676 creator A5059250686 @default.
• W1536611676 creator A5061155266 @default.
• W1536611676 creator A5082500942 @default.
• W1536611676 creator A5089253558 @default.
• W1536611676 date "2014-12-11" @default.
• W1536611676 modified "2023-10-16" @default.
• W1536611676 title "Striatal shape abnormalities as novel neurodevelopmental endophenotypes in schizophrenia: A longitudinal study" @default.
• W1536611676 cites W1573734345 @default.
• W1536611676 cites W1601443637 @default.
• W1536611676 cites W161257794 @default.
• W1536611676 cites W177664770 @default.
• W1536611676 cites W1891773028 @default.
• W1536611676 cites W1964060454 @default.
• W1536611676 cites W1964282208 @default.
• W1536611676 cites W1966358829 @default.
• W1536611676 cites W1970804655 @default.
• W1536611676 cites W1979966786 @default.
• W1536611676 cites W1981463159 @default.
• W1536611676 cites W1987670570 @default.
• W1536611676 cites W1991456242 @default.
• W1536611676 cites W1994757008 @default.
• W1536611676 cites W1995195434 @default.
• W1536611676 cites W1995362640 @default.
• W1536611676 cites W1997381140 @default.
• W1536611676 cites W2002782093 @default.
• W1536611676 cites W2004004650 @default.
• W1536611676 cites W2005112198 @default.
• W1536611676 cites W2008395212 @default.
• W1536611676 cites W2009801894 @default.
• W1536611676 cites W2009995715 @default.
• W1536611676 cites W2010837501 @default.
• W1536611676 cites W2011481459 @default.
• W1536611676 cites W2014827051 @default.
• W1536611676 cites W2015423460 @default.
• W1536611676 cites W2018427609 @default.
• W1536611676 cites W2022782092 @default.
• W1536611676 cites W2023761384 @default.
• W1536611676 cites W2024341316 @default.
• W1536611676 cites W2026446822 @default.
• W1536611676 cites W2026896885 @default.
• W1536611676 cites W2028311481 @default.
• W1536611676 cites W2031170958 @default.
• W1536611676 cites W2034457280 @default.
• W1536611676 cites W2037689983 @default.
• W1536611676 cites W2038012828 @default.
• W1536611676 cites W2039067474 @default.
• W1536611676 cites W2040073285 @default.
• W1536611676 cites W2040635916 @default.
• W1536611676 cites W2041689182 @default.
• W1536611676 cites W2044489210 @default.
• W1536611676 cites W2051942459 @default.
• W1536611676 cites W2062648684 @default.
• W1536611676 cites W2064629965 @default.
• W1536611676 cites W2065883186 @default.
• W1536611676 cites W2069430900 @default.
• W1536611676 cites W2069661631 @default.
• W1536611676 cites W2069922847 @default.
• W1536611676 cites W2070368610 @default.
• W1536611676 cites W2072714066 @default.
• W1536611676 cites W2074417925 @default.
• W1536611676 cites W2076133825 @default.
• W1536611676 cites W2076265586 @default.
• W1536611676 cites W2078339393 @default.
• W1536611676 cites W2079203989 @default.
• W1536611676 cites W2079227251 @default.
• W1536611676 cites W2084349630 @default.
• W1536611676 cites W2095832213 @default.
• W1536611676 cites W2096570254 @default.
• W1536611676 cites W2099921986 @default.
• W1536611676 cites W2109216757 @default.
• W1536611676 cites W2111456519 @default.
• W1536611676 cites W2113758182 @default.
• W1536611676 cites W2113902248 @default.
• W1536611676 cites W2118649142 @default.
• W1536611676 cites W2120731293 @default.
• W1536611676 cites W2122739133 @default.
• W1536611676 cites W2123547278 @default.
• W1536611676 cites W2123820408 @default.
• W1536611676 cites W2129558945 @default.
• W1536611676 cites W2131051578 @default.
• W1536611676 cites W2131564374 @default.
• W1536611676 cites W2135333366 @default.
• W1536611676 cites W2135734842 @default.
• W1536611676 cites W2136148445 @default.
• W1536611676 cites W2138146369 @default.
• W1536611676 cites W2140261180 @default.
• W1536611676 cites W2143463042 @default.
• W1536611676 cites W2145754751 @default.
• W1536611676 cites W2148201341 @default.
• W1536611676 cites W2148953407 @default.
• W1536611676 cites W2150487695 @default.
• W1536611676 cites W2151331628 @default.

• next