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• W1536643155 endingPage "65" @default.
• W1536643155 startingPage "43" @default.
• W1536643155 abstract "This chapter summarizes mechanisms that control the development of retinotopic maps in the brain, focusing on work from our laboratory using as models the projection of retinal ganglion cells (RGCs) to the chick optic tectum (OT) or rodent superior colliculus (SC). The formation of a retinotopic map involves the establishment of an initial, very coarse map that subsequently undergoes large-scale remodeling to generate a refined map. All arbors are formed by interstitial branches that form in a topographically biased manner along RGC axons that overshoot their correct termination zone (TZ) along the anterior-posterior (A-P) axis of the OT/SC. The interstitial branches exhibit directed growth along the lateral-medial (L-M) axis of the OT/SC to position the branch at the topographically correct location, where it arborizes to form the TZ. EphA receptors and ephrin-A ligands control in part RGC axon mapping along the A-P axis by inhibiting branching and arborization posterior to the correct TZ. Ephrin-B1 acts bifunctionally through EphB forward signaling to direct branches along the L-M axis of the OT/SC to their topographically correct site. Computational modeling indicates that multiple graded activities are required along each axis to generate a retinotopic map, and makes several predictions, including: the progressive addition of ephrin-As within the OT/SC, due to its expression on RGC axon branches and arbors, is required to increase topographic specificity in branching and arborization as well as eliminate the initial axon overshoot, and that interactions amongst RGC axons that resemble correlated neural activity are required to drive retinotopic refinement. Analyses of mutant mice that lack early spontaneous retinal waves that correlate activity amongst neighboring RGCs, confirm this modeling prediction and show that correlated activity during an early brief critical period is required to drive the large-scale remodeling of the initially topographically coarse projection into a refined one. In summary, multiple graded guidance molecules, retinal waves and correlated spontaneous RGC activity cooperate to generate retinotopic maps." @default.
• W1536643155 created "2016-06-24" @default.
• W1536643155 creator A5012926933 @default.
• W1536643155 creator A5054032631 @default.
• W1536643155 date "2005-01-01" @default.
• W1536643155 modified "2023-10-16" @default.
• W1536643155 title "Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity" @default.
• W1536643155 cites W1501558564 @default.
• W1536643155 cites W1532382772 @default.
• W1536643155 cites W1545529134 @default.
• W1536643155 cites W1553730410 @default.
• W1536643155 cites W1566057084 @default.
• W1536643155 cites W1571948966 @default.
• W1536643155 cites W1573261410 @default.
• W1536643155 cites W1578782149 @default.
• W1536643155 cites W1597356000 @default.
• W1536643155 cites W1600079321 @default.
• W1536643155 cites W1611891438 @default.
• W1536643155 cites W1647008873 @default.
• W1536643155 cites W1664668314 @default.
• W1536643155 cites W1760016749 @default.
• W1536643155 cites W1830398839 @default.
• W1536643155 cites W1831348067 @default.
• W1536643155 cites W1904476764 @default.
• W1536643155 cites W1920858933 @default.
• W1536643155 cites W1953807893 @default.
• W1536643155 cites W1975196303 @default.
• W1536643155 cites W1977413405 @default.
• W1536643155 cites W1977455576 @default.
• W1536643155 cites W1978256637 @default.
• W1536643155 cites W1978415644 @default.
• W1536643155 cites W1982024326 @default.
• W1536643155 cites W1982845356 @default.
• W1536643155 cites W1983134628 @default.
• W1536643155 cites W1984755886 @default.
• W1536643155 cites W1987237521 @default.
• W1536643155 cites W1992111877 @default.
• W1536643155 cites W1992764788 @default.
• W1536643155 cites W1995374378 @default.
• W1536643155 cites W2001627575 @default.
• W1536643155 cites W2003339050 @default.
• W1536643155 cites W2010250841 @default.
• W1536643155 cites W2012922512 @default.
• W1536643155 cites W2014764883 @default.
• W1536643155 cites W2015378446 @default.
• W1536643155 cites W2019203033 @default.
• W1536643155 cites W2020634566 @default.
• W1536643155 cites W2021025315 @default.
• W1536643155 cites W2021814062 @default.
• W1536643155 cites W2027846728 @default.
• W1536643155 cites W2037272215 @default.
• W1536643155 cites W2038811268 @default.
• W1536643155 cites W2042603409 @default.
• W1536643155 cites W2042902655 @default.
• W1536643155 cites W2043562994 @default.
• W1536643155 cites W2046473105 @default.
• W1536643155 cites W2047262515 @default.
• W1536643155 cites W2048061086 @default.
• W1536643155 cites W2048102112 @default.
• W1536643155 cites W2049128931 @default.
• W1536643155 cites W2051106202 @default.
• W1536643155 cites W2052500847 @default.
• W1536643155 cites W2057050792 @default.
• W1536643155 cites W2058861807 @default.
• W1536643155 cites W2061737733 @default.
• W1536643155 cites W2069306062 @default.
• W1536643155 cites W2070178752 @default.
• W1536643155 cites W2072244168 @default.
• W1536643155 cites W2072378189 @default.
• W1536643155 cites W2074284246 @default.
• W1536643155 cites W2074345277 @default.
• W1536643155 cites W2074422606 @default.
• W1536643155 cites W2075109584 @default.
• W1536643155 cites W2083579647 @default.
• W1536643155 cites W2085817315 @default.
• W1536643155 cites W2090505541 @default.
• W1536643155 cites W2108613636 @default.
• W1536643155 cites W2109121146 @default.
• W1536643155 cites W2112659765 @default.
• W1536643155 cites W2112906768 @default.
• W1536643155 cites W2120760119 @default.
• W1536643155 cites W2120904665 @default.
• W1536643155 cites W2121952955 @default.
• W1536643155 cites W2122587655 @default.
• W1536643155 cites W2126548263 @default.
• W1536643155 cites W2129076056 @default.
• W1536643155 cites W2129387324 @default.
• W1536643155 cites W2133093591 @default.
• W1536643155 cites W2135132703 @default.
• W1536643155 cites W2138505246 @default.
• W1536643155 cites W2140067862 @default.
• W1536643155 cites W2141895876 @default.
• W1536643155 cites W2142190178 @default.
• W1536643155 cites W2151788312 @default.
• W1536643155 cites W2151949105 @default.
• W1536643155 cites W2157585888 @default.
• W1536643155 cites W2157622411 @default.
• W1536643155 cites W2159692628 @default.

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