FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536686934> ?p ?o ?g. }

• W1536686934 endingPage "1515" @default.
• W1536686934 startingPage "1497" @default.
• W1536686934 abstract "1. The involvement of excitatory amino acid (EAA) receptors in the generation of respiratory rhythm and transmission of inspiratory drive to hypoglossal (XII) motoneurons was examined in an in vitro neonatal rat medullary slice preparation. Slices generated rhythmic inspiratory activity in XII nerves. The role of EAAs in rhythm generation was determined by analyzing perturbations of respiratory network activity after bath application of EAA receptor antagonists or local microinjection of antagonists into the main column of respiratory neurons in the ventrolateral medulla (ventral respiratory group), particularly in the pre-Bötzinger complex (pre-BötC). The involvement of EAAs in drive transmission to XII motoneurons was examined by recording perturbations in XII nerve discharge or motoneuron synaptic inputs after microinjection of EAA receptor antagonists into either the XII motor nuclei or sites in the ventrolateral medulla containing interneurons of the drive transmission circuit. 2. Block of non-N-methyl-D-aspartate (non-NMDA) receptors by bath application of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reversibly reduced XII nerve burst frequency and amplitude in a concentration-dependent manner, completely blocking respiratory motor output at concentrations > 4 microM. Activation of 2-amino-4-phosphonobutyric acid (AP-4)-sensitive receptors with D,L AP-4 reduced XII nerve burst amplitude by 30% but did not alter burst frequency. Block of NMDA receptor channels by bath application of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-iminemaleate (MK-801) did not perturb the frequency or amplitude of motor output. Inhibition of EAA uptake in the slices by bath application of dihydrokainic acid reversibly increased the frequency and amplitude of XII motor discharge. 3. Block of non-NMDA receptors at multiple sites along the main column of respiratory neurons in the ventrolateral medulla, including the pre-BötC, by unilateral microinjection of CNQX produced a dose-dependent, bilateral reduction in XII nerve burst amplitude without substantial perturbations of the frequency of respiratory oscillations. Block of non-NMDA receptors within the pre-BötC at sites ventral to amplitude altering sites produced a reduction in frequency and ultimately bilateral block of respiratory network oscillations. 4. Non-NMDA receptor block within the XII motor nucleus by unilateral microinjection of CNQX produced a dose-dependent reduction in ipsilateral XII nerve discharge amplitude without perturbing the frequency of respiratory oscillations. Perturbations of contralateral XII nerve burst amplitude were significantly smaller. NMDA channel block within the XII motor nucleus did not affect inspiratory burst amplitude, whereas activation of AP-4 receptors caused a 30% reduction in amplitude." @default.
• W1536686934 created "2016-06-24" @default.
• W1536686934 creator A5025482808 @default.
• W1536686934 creator A5034558153 @default.
• W1536686934 creator A5064975604 @default.
• W1536686934 date "1993-10-01" @default.
• W1536686934 modified "2023-09-30" @default.
• W1536686934 title "Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids" @default.
• W1536686934 cites W1481205391 @default.
• W1536686934 cites W1547399881 @default.
• W1536686934 cites W1558119278 @default.
• W1536686934 cites W1658711792 @default.
• W1536686934 cites W1988659111 @default.
• W1536686934 cites W1990051014 @default.
• W1536686934 cites W1990489079 @default.
• W1536686934 cites W1995056605 @default.
• W1536686934 cites W1996892917 @default.
• W1536686934 cites W1998746881 @default.
• W1536686934 cites W2002919913 @default.
• W1536686934 cites W2004845912 @default.
• W1536686934 cites W2007632407 @default.
• W1536686934 cites W2009030798 @default.
• W1536686934 cites W2020019881 @default.
• W1536686934 cites W2023657406 @default.
• W1536686934 cites W2026815588 @default.
• W1536686934 cites W2031699618 @default.
• W1536686934 cites W2037688283 @default.
• W1536686934 cites W2041734573 @default.
• W1536686934 cites W2050230820 @default.
• W1536686934 cites W2053666664 @default.
• W1536686934 cites W2057537207 @default.
• W1536686934 cites W2067421400 @default.
• W1536686934 cites W2067563896 @default.
• W1536686934 cites W2069713657 @default.
• W1536686934 cites W2086246680 @default.
• W1536686934 cites W2093021229 @default.
• W1536686934 cites W2099834228 @default.
• W1536686934 cites W2102336716 @default.
• W1536686934 cites W2107177197 @default.
• W1536686934 cites W2143309374 @default.
• W1536686934 cites W2150595146 @default.
• W1536686934 cites W2151361666 @default.
• W1536686934 cites W2155760129 @default.
• W1536686934 cites W2234934158 @default.
• W1536686934 cites W2256546102 @default.
• W1536686934 cites W3024959144 @default.
• W1536686934 doi "https://doi.org/10.1152/jn.1993.70.4.1497" @default.
• W1536686934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8283211" @default.
• W1536686934 hasPublicationYear "1993" @default.
• W1536686934 type Work @default.
• W1536686934 sameAs 1536686934 @default.
• W1536686934 citedByCount "306" @default.
• W1536686934 countsByYear W15366869342012 @default.
• W1536686934 countsByYear W15366869342013 @default.
• W1536686934 countsByYear W15366869342014 @default.
• W1536686934 countsByYear W15366869342015 @default.
• W1536686934 countsByYear W15366869342016 @default.
• W1536686934 countsByYear W15366869342017 @default.
• W1536686934 countsByYear W15366869342018 @default.
• W1536686934 countsByYear W15366869342019 @default.
• W1536686934 countsByYear W15366869342020 @default.
• W1536686934 countsByYear W15366869342021 @default.
• W1536686934 countsByYear W15366869342022 @default.
• W1536686934 countsByYear W15366869342023 @default.
• W1536686934 crossrefType "journal-article" @default.
• W1536686934 hasAuthorship W1536686934A5025482808 @default.
• W1536686934 hasAuthorship W1536686934A5034558153 @default.
• W1536686934 hasAuthorship W1536686934A5064975604 @default.
• W1536686934 hasConcept C105702510 @default.
• W1536686934 hasConcept C112592302 @default.
• W1536686934 hasConcept C12554922 @default.
• W1536686934 hasConcept C134018914 @default.
• W1536686934 hasConcept C160268369 @default.
• W1536686934 hasConcept C169760540 @default.
• W1536686934 hasConcept C170493617 @default.
• W1536686934 hasConcept C17291353 @default.
• W1536686934 hasConcept C185592680 @default.
• W1536686934 hasConcept C200170125 @default.
• W1536686934 hasConcept C2778110749 @default.
• W1536686934 hasConcept C2779803574 @default.
• W1536686934 hasConcept C2780648746 @default.
• W1536686934 hasConcept C2780906327 @default.
• W1536686934 hasConcept C29694410 @default.
• W1536686934 hasConcept C33114225 @default.
• W1536686934 hasConcept C529278444 @default.
• W1536686934 hasConcept C534529494 @default.
• W1536686934 hasConcept C55493867 @default.
• W1536686934 hasConcept C61174792 @default.
• W1536686934 hasConcept C62525196 @default.
• W1536686934 hasConcept C67018056 @default.
• W1536686934 hasConcept C86803240 @default.
• W1536686934 hasConceptScore W1536686934C105702510 @default.
• W1536686934 hasConceptScore W1536686934C112592302 @default.
• W1536686934 hasConceptScore W1536686934C12554922 @default.
• W1536686934 hasConceptScore W1536686934C134018914 @default.
• W1536686934 hasConceptScore W1536686934C160268369 @default.
• W1536686934 hasConceptScore W1536686934C169760540 @default.
• W1536686934 hasConceptScore W1536686934C170493617 @default.

• next