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• W1536691681 startingPage "6009" @default.
• W1536691681 abstract "Abstract The polymeric Ig receptor (pIgR) and J chain molecules are involved in the transfer of IgA across the mammary gland epithelia into milk. The J chain binds two IgA molecules to form dimeric IgA, and the pIgR transports this complex through epithelial cells. We report here the cloning of the first marsupial homologues for the pIgR and J chain from the brushtail possum. Marsupial young are born after a short gestation and are less developed than eutherian newborn. The pouch young is completely dependent on milk as its sole source of nutrition during early lactation and this phase can be considered to be equivalent to an external gestation. Two periods of increased expression of pIgR, J chain, and IgA heavy chain mRNAs were observed in the mammary gland during lactation. The first occurs for a brief period after birth of the pouch young and is likely to reflect IgA transfer via the colostrum. The second period of increased expression, which is unique to marsupials, occurs after the early lactation period and just before young exit the pouch. We propose that this represents a second colostral-like phase at the end of the external gestation." @default.
• W1536691681 created "2016-06-24" @default.
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• W1536691681 date "1999-05-15" @default.
• W1536691681 modified "2023-10-10" @default.
• W1536691681 title "Two Stages of Increased IgA Transfer During Lactation in the Marsupial,<i>Trichosurus vulpecula</i>(Brushtail Possum)" @default.
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• W1536691681 doi "https://doi.org/10.4049/jimmunol.162.10.6009" @default.
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