Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536693692> ?p ?o ?g. }
- W1536693692 endingPage "1150" @default.
- W1536693692 startingPage "1140" @default.
- W1536693692 abstract "Abstract During development, thymocytes carrying TCRs mediating low-affinity interactions with MHC-bound self-peptides are positively selected for export into the mature peripheral T lymphocyte pool. Thus, exogenous administration of certain altered peptide ligands (APL) with reduced TCR affinity relative to cognate Ags may provide a tool to elicit maturation of desired TCR specificities. To test this “thymic vaccination” concept, we designed APL of the viral CTL epitopes gp33–41 and vesicular stomatitis virus nucleoprotein octapeptide N52–59 relevant for the lymphocytic choriomeningitis virus-specific P14- and vesicular stomatitis virus-specific N15-TCRs, respectively, and examined their effects on thymocytes in vivo using irradiation chimeras. Injection of APL into irradiated congenic (Ly-5.1) mice, reconstituted with T cell progenitors from the bone marrow of P14 RAG2−/− (Ly-5.2) or N15 RAG2−/− (Ly-5.2) transgenic mice, resulted in positive selection of T cells expressing the relevant specificity. Moreover, the variants led to export of virus-specific T cells to lymph nodes, but without inducing T cell proliferation. These findings show that the mature T cell repertoire can be altered by in vivo peptide administration through manipulation of thymic selection." @default.
- W1536693692 created "2016-06-24" @default.
- W1536693692 creator A5013709830 @default.
- W1536693692 creator A5025546339 @default.
- W1536693692 creator A5051034667 @default.
- W1536693692 date "2004-07-15" @default.
- W1536693692 modified "2023-10-02" @default.
- W1536693692 title "Peptide Variants of Viral CTL Epitopes Mediate Positive Selection and Emigration of Ag-Specific Thymocytes In Vivo" @default.
- W1536693692 cites W1567355347 @default.
- W1536693692 cites W1598248804 @default.
- W1536693692 cites W1614901871 @default.
- W1536693692 cites W1670704749 @default.
- W1536693692 cites W1959677146 @default.
- W1536693692 cites W1971141213 @default.
- W1536693692 cites W1972966267 @default.
- W1536693692 cites W1975503309 @default.
- W1536693692 cites W1977892868 @default.
- W1536693692 cites W1978720797 @default.
- W1536693692 cites W1988389319 @default.
- W1536693692 cites W1993435809 @default.
- W1536693692 cites W1998074063 @default.
- W1536693692 cites W2003582386 @default.
- W1536693692 cites W2004145329 @default.
- W1536693692 cites W2004680217 @default.
- W1536693692 cites W2004826057 @default.
- W1536693692 cites W2013798742 @default.
- W1536693692 cites W2016768070 @default.
- W1536693692 cites W2022613174 @default.
- W1536693692 cites W2035491054 @default.
- W1536693692 cites W2036419095 @default.
- W1536693692 cites W2041061869 @default.
- W1536693692 cites W2043485104 @default.
- W1536693692 cites W2045008512 @default.
- W1536693692 cites W2046816269 @default.
- W1536693692 cites W2047528341 @default.
- W1536693692 cites W2049675300 @default.
- W1536693692 cites W2059637973 @default.
- W1536693692 cites W2068746444 @default.
- W1536693692 cites W2074760724 @default.
- W1536693692 cites W2091257232 @default.
- W1536693692 cites W2095505221 @default.
- W1536693692 cites W2097204483 @default.
- W1536693692 cites W2104207674 @default.
- W1536693692 cites W2111686340 @default.
- W1536693692 cites W2114569569 @default.
- W1536693692 cites W2128106363 @default.
- W1536693692 cites W2130718104 @default.
- W1536693692 cites W2142381543 @default.
- W1536693692 cites W2147915567 @default.
- W1536693692 cites W2149664101 @default.
- W1536693692 cites W2157176418 @default.
- W1536693692 cites W2164537558 @default.
- W1536693692 cites W2166630199 @default.
- W1536693692 cites W2172172883 @default.
- W1536693692 cites W2174800991 @default.
- W1536693692 cites W31913422 @default.
- W1536693692 cites W4211059834 @default.
- W1536693692 cites W4239544480 @default.
- W1536693692 doi "https://doi.org/10.4049/jimmunol.173.2.1140" @default.
- W1536693692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15240703" @default.
- W1536693692 hasPublicationYear "2004" @default.
- W1536693692 type Work @default.
- W1536693692 sameAs 1536693692 @default.
- W1536693692 citedByCount "11" @default.
- W1536693692 countsByYear W15366936922012 @default.
- W1536693692 countsByYear W15366936922014 @default.
- W1536693692 countsByYear W15366936922019 @default.
- W1536693692 countsByYear W15366936922023 @default.
- W1536693692 crossrefType "journal-article" @default.
- W1536693692 hasAuthorship W1536693692A5013709830 @default.
- W1536693692 hasAuthorship W1536693692A5025546339 @default.
- W1536693692 hasAuthorship W1536693692A5051034667 @default.
- W1536693692 hasBestOaLocation W15366936921 @default.
- W1536693692 hasConcept C104317684 @default.
- W1536693692 hasConcept C141231307 @default.
- W1536693692 hasConcept C147483822 @default.
- W1536693692 hasConcept C147969180 @default.
- W1536693692 hasConcept C153911025 @default.
- W1536693692 hasConcept C159047783 @default.
- W1536693692 hasConcept C167672396 @default.
- W1536693692 hasConcept C19317047 @default.
- W1536693692 hasConcept C195616568 @default.
- W1536693692 hasConcept C203014093 @default.
- W1536693692 hasConcept C207001950 @default.
- W1536693692 hasConcept C2522874641 @default.
- W1536693692 hasConcept C2776090121 @default.
- W1536693692 hasConcept C2778954852 @default.
- W1536693692 hasConcept C2779057330 @default.
- W1536693692 hasConcept C2780190958 @default.
- W1536693692 hasConcept C54355233 @default.
- W1536693692 hasConcept C55493867 @default.
- W1536693692 hasConcept C7386963 @default.
- W1536693692 hasConcept C86803240 @default.
- W1536693692 hasConcept C8891405 @default.
- W1536693692 hasConcept C95444343 @default.
- W1536693692 hasConceptScore W1536693692C104317684 @default.
- W1536693692 hasConceptScore W1536693692C141231307 @default.
- W1536693692 hasConceptScore W1536693692C147483822 @default.