FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536705765> ?p ?o ?g. }

• W1536705765 endingPage "22045" @default.
• W1536705765 startingPage "22042" @default.
• W1536705765 abstract "A growing body of evidence suggests that a variety of chronic diseases, including cancer and diabetes, are associated with damage to mitochondrial DNA. Since mitochondria are constantly exposed to high levels of reactive oxygen species, it is likely that oxidative damage to mitochondrial DNA may be responsible for some of these maladies. To determine whether mitochondria can repair this damage, a quantitative Southern blot technique was utilized to identify repair in specific DNA fragments. A 10.8-kilobase mitochondrial restriction fragment was studied employing a probe containing the entire mouse mitochondrial genome. Alloxan was employed to generate oxygen radicals. Insulinoma cells were exposed to alloxan for 1 h, and total cellular DNA was isolated immediately or after intervals of up to 8 h. Alkali treatment was used to identify abasic sites and sugar lesions, endonuclease III was used to identify lesions associated with thymine and cytosine damage, and formamidopyrimidine-DNA glycosylase was employed to recognize formamidopyrimidines and 8-oxoguanines in DNA. The results showed that all forms of damage studied were repaired by 4 h, indicating that mitochondria are able to efficiently repair damage to their DNA caused by reactive oxygen species." @default.
• W1536705765 created "2016-06-24" @default.
• W1536705765 creator A5032186531 @default.
• W1536705765 creator A5064426835 @default.
• W1536705765 creator A5073542191 @default.
• W1536705765 date "1993-10-01" @default.
• W1536705765 modified "2023-10-14" @default.
• W1536705765 title "Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells." @default.
• W1536705765 cites W1487996877 @default.
• W1536705765 cites W1491701960 @default.
• W1536705765 cites W1570947397 @default.
• W1536705765 cites W1589124205 @default.
• W1536705765 cites W1970561813 @default.
• W1536705765 cites W1975394073 @default.
• W1536705765 cites W1984496481 @default.
• W1536705765 cites W1988209444 @default.
• W1536705765 cites W1997890801 @default.
• W1536705765 cites W2000741385 @default.
• W1536705765 cites W2001565942 @default.
• W1536705765 cites W2007985488 @default.
• W1536705765 cites W2008073713 @default.
• W1536705765 cites W2011906490 @default.
• W1536705765 cites W2016073900 @default.
• W1536705765 cites W2018185503 @default.
• W1536705765 cites W2019039833 @default.
• W1536705765 cites W2029007583 @default.
• W1536705765 cites W2039006304 @default.
• W1536705765 cites W2041683774 @default.
• W1536705765 cites W2046619774 @default.
• W1536705765 cites W2048339025 @default.
• W1536705765 cites W2048549839 @default.
• W1536705765 cites W2064502414 @default.
• W1536705765 cites W2068032719 @default.
• W1536705765 cites W2068568687 @default.
• W1536705765 cites W2077414996 @default.
• W1536705765 cites W2089948029 @default.
• W1536705765 cites W2097432692 @default.
• W1536705765 cites W2108747861 @default.
• W1536705765 cites W2127849793 @default.
• W1536705765 cites W2132826785 @default.
• W1536705765 cites W2614442853 @default.
• W1536705765 doi "https://doi.org/10.1016/s0021-9258(20)80645-0" @default.
• W1536705765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8408062" @default.
• W1536705765 hasPublicationYear "1993" @default.
• W1536705765 type Work @default.
• W1536705765 sameAs 1536705765 @default.
• W1536705765 citedByCount "164" @default.
• W1536705765 countsByYear W15367057652012 @default.
• W1536705765 countsByYear W15367057652013 @default.
• W1536705765 countsByYear W15367057652015 @default.
• W1536705765 countsByYear W15367057652016 @default.
• W1536705765 countsByYear W15367057652017 @default.
• W1536705765 countsByYear W15367057652018 @default.
• W1536705765 countsByYear W15367057652020 @default.
• W1536705765 countsByYear W15367057652021 @default.
• W1536705765 countsByYear W15367057652022 @default.
• W1536705765 crossrefType "journal-article" @default.
• W1536705765 hasAuthorship W1536705765A5032186531 @default.
• W1536705765 hasAuthorship W1536705765A5064426835 @default.
• W1536705765 hasAuthorship W1536705765A5073542191 @default.
• W1536705765 hasBestOaLocation W15367057651 @default.
• W1536705765 hasConcept C104317684 @default.
• W1536705765 hasConcept C143425029 @default.
• W1536705765 hasConcept C185592680 @default.
• W1536705765 hasConcept C24586158 @default.
• W1536705765 hasConcept C2776151105 @default.
• W1536705765 hasConcept C28859421 @default.
• W1536705765 hasConcept C3020296196 @default.
• W1536705765 hasConcept C552990157 @default.
• W1536705765 hasConcept C55493867 @default.
• W1536705765 hasConcept C57600042 @default.
• W1536705765 hasConcept C86803240 @default.
• W1536705765 hasConcept C95444343 @default.
• W1536705765 hasConceptScore W1536705765C104317684 @default.
• W1536705765 hasConceptScore W1536705765C143425029 @default.
• W1536705765 hasConceptScore W1536705765C185592680 @default.
• W1536705765 hasConceptScore W1536705765C24586158 @default.
• W1536705765 hasConceptScore W1536705765C2776151105 @default.
• W1536705765 hasConceptScore W1536705765C28859421 @default.
• W1536705765 hasConceptScore W1536705765C3020296196 @default.
• W1536705765 hasConceptScore W1536705765C552990157 @default.
• W1536705765 hasConceptScore W1536705765C55493867 @default.
• W1536705765 hasConceptScore W1536705765C57600042 @default.
• W1536705765 hasConceptScore W1536705765C86803240 @default.
• W1536705765 hasConceptScore W1536705765C95444343 @default.
• W1536705765 hasIssue "29" @default.
• W1536705765 hasLocation W15367057651 @default.
• W1536705765 hasOpenAccess W1536705765 @default.
• W1536705765 hasPrimaryLocation W15367057651 @default.
• W1536705765 hasRelatedWork W1926649163 @default.
• W1536705765 hasRelatedWork W2003937841 @default.
• W1536705765 hasRelatedWork W2012798724 @default.
• W1536705765 hasRelatedWork W2028354105 @default.
• W1536705765 hasRelatedWork W2035609552 @default.
• W1536705765 hasRelatedWork W2050478585 @default.
• W1536705765 hasRelatedWork W2115505412 @default.
• W1536705765 hasRelatedWork W2373717753 @default.
• W1536705765 hasRelatedWork W2382922633 @default.

• next