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- W1536728832 abstract "Airway remodeling is present in the bronchi of asthmatics and may account for poor response to treatment in individuals with refractory disease. Fibrosis and angiogenesis are key features of remodeling. Multiple factors present in the asthmatic airway contribute to fibrosis and angiogenesis and are therefore potential targets for the development of new antiremodeling therapies. We review the major profibrotic factors that contribute to remodeling in asthma, including transforming growth factor β, platelet-derived growth factor, fibroblast growth factor, epidermal growth factor, connective tissue growth factor, interleukin 13, endothelin, osteopontin, eotaxins, and extracellular matrix components such as fibronectin. Angiogenic factors include vascular endothelial growth factor, nerve growth factor, angiopoeitin, angiogenin, and endothelin. Mention is also made of endogenous inhibitors of angiogenesis, namely angiostatin and endostatin. For each factor, we review the biology and evidence that they are involved in asthma, and discuss these molecules as potential new therapeutic targets. We also briefly review the contribution of eosinophils to angiogenesis in asthma." @default.
- W1536728832 created "2016-06-24" @default.
- W1536728832 creator A5022633507 @default.
- W1536728832 creator A5054584900 @default.
- W1536728832 date "2011-07-27" @default.
- W1536728832 modified "2023-09-26" @default.
- W1536728832 title "Profibrotic and Angiogenic Factors in Asthma" @default.
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