Matches in SemOpenAlex for { <https://semopenalex.org/work/W1536735543> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1536735543 endingPage "7930" @default.
- W1536735543 startingPage "7924" @default.
- W1536735543 abstract "The mechanism of cholinergic stimulation of alanine and glutamine formation and release from skeletal muscle was studied using rat epitrochlaris preparations. The increased alanine and glutamine release produced by carbamylcholine (10(-6) M) was reproduced by tetramethylammonium (10(-6) M) but not by pilocarpine (10(-6) M) and was blocked by hexamethonium (10(-4) M) but not by atropine (10(-7) M). This increased alanine and glutamine release was not associated with altered muscle cAMP levels. However, carbamylcholine (10(-6) M) and tetramethylammonium (10(-6) M) did not increase levels of cGMP, 134% and 101%, respectively, and these increments in cGMP were blocked by hexamethonium but not by atropine. Carbamylcholine produced a concentration-dependent increase in cGMP levels. Methylisobutylxanthine and theophylline augmented the increased amino acid release and increased cGMP levels produced by carbamylcholine. Neither xanthine derivative alone altered alanine and glutamine release or cyclic nucleotide levels. Added cGMP increased amino acid release and the uptake of [U-14C]alanine and alpha-amino[14C]isobutyric acid. Carbamylcholine did not alter muscle phosphorylase a activity, glycogen levels, or basal adenylate cyclase activity. These data indicate that cholinergic stimulation of muscle alanine and glutamine formation and release involves a nicotinic cholinergic receptor and may be mediated by increased levels of cGMP, which in turn may result from a cholinergic stimulation of muscle guanylyl cyclase." @default.
- W1536735543 created "2016-06-24" @default.
- W1536735543 creator A5003363567 @default.
- W1536735543 creator A5046577754 @default.
- W1536735543 creator A5076048620 @default.
- W1536735543 date "1978-11-01" @default.
- W1536735543 modified "2023-09-30" @default.
- W1536735543 title "Cholinergic stimulation of skeletal muscle alanine and glutamine formation and release. Evidence for mediation by a nicotinic cholinergic receptor and guanosine 3‘:5‘-monophosphate" @default.
- W1536735543 cites W1483387535 @default.
- W1536735543 cites W1486608945 @default.
- W1536735543 cites W1497964877 @default.
- W1536735543 cites W1502086746 @default.
- W1536735543 cites W1518913349 @default.
- W1536735543 cites W1537356591 @default.
- W1536735543 cites W1589012184 @default.
- W1536735543 cites W1594016069 @default.
- W1536735543 cites W1595626863 @default.
- W1536735543 cites W1775749144 @default.
- W1536735543 cites W1830931920 @default.
- W1536735543 cites W1965522813 @default.
- W1536735543 cites W1982218403 @default.
- W1536735543 cites W2000027962 @default.
- W1536735543 cites W2025873962 @default.
- W1536735543 cites W2031233656 @default.
- W1536735543 cites W2049875449 @default.
- W1536735543 cites W2169503005 @default.
- W1536735543 doi "https://doi.org/10.1016/s0021-9258(17)34460-5" @default.
- W1536735543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/81208" @default.
- W1536735543 hasPublicationYear "1978" @default.
- W1536735543 type Work @default.
- W1536735543 sameAs 1536735543 @default.
- W1536735543 citedByCount "15" @default.
- W1536735543 crossrefType "journal-article" @default.
- W1536735543 hasAuthorship W1536735543A5003363567 @default.
- W1536735543 hasAuthorship W1536735543A5046577754 @default.
- W1536735543 hasAuthorship W1536735543A5076048620 @default.
- W1536735543 hasBestOaLocation W15367355431 @default.
- W1536735543 hasConcept C126322002 @default.
- W1536735543 hasConcept C134018914 @default.
- W1536735543 hasConcept C170493617 @default.
- W1536735543 hasConcept C17744445 @default.
- W1536735543 hasConcept C179420905 @default.
- W1536735543 hasConcept C185592680 @default.
- W1536735543 hasConcept C188987157 @default.
- W1536735543 hasConcept C199539241 @default.
- W1536735543 hasConcept C22885893 @default.
- W1536735543 hasConcept C24998067 @default.
- W1536735543 hasConcept C2777995097 @default.
- W1536735543 hasConcept C2779349466 @default.
- W1536735543 hasConcept C2780994212 @default.
- W1536735543 hasConcept C515207424 @default.
- W1536735543 hasConcept C519581460 @default.
- W1536735543 hasConcept C55493867 @default.
- W1536735543 hasConcept C71924100 @default.
- W1536735543 hasConcept C86803240 @default.
- W1536735543 hasConceptScore W1536735543C126322002 @default.
- W1536735543 hasConceptScore W1536735543C134018914 @default.
- W1536735543 hasConceptScore W1536735543C170493617 @default.
- W1536735543 hasConceptScore W1536735543C17744445 @default.
- W1536735543 hasConceptScore W1536735543C179420905 @default.
- W1536735543 hasConceptScore W1536735543C185592680 @default.
- W1536735543 hasConceptScore W1536735543C188987157 @default.
- W1536735543 hasConceptScore W1536735543C199539241 @default.
- W1536735543 hasConceptScore W1536735543C22885893 @default.
- W1536735543 hasConceptScore W1536735543C24998067 @default.
- W1536735543 hasConceptScore W1536735543C2777995097 @default.
- W1536735543 hasConceptScore W1536735543C2779349466 @default.
- W1536735543 hasConceptScore W1536735543C2780994212 @default.
- W1536735543 hasConceptScore W1536735543C515207424 @default.
- W1536735543 hasConceptScore W1536735543C519581460 @default.
- W1536735543 hasConceptScore W1536735543C55493867 @default.
- W1536735543 hasConceptScore W1536735543C71924100 @default.
- W1536735543 hasConceptScore W1536735543C86803240 @default.
- W1536735543 hasIssue "21" @default.
- W1536735543 hasLocation W15367355431 @default.
- W1536735543 hasOpenAccess W1536735543 @default.
- W1536735543 hasPrimaryLocation W15367355431 @default.
- W1536735543 hasRelatedWork W1984619393 @default.
- W1536735543 hasRelatedWork W2034583712 @default.
- W1536735543 hasRelatedWork W2034768996 @default.
- W1536735543 hasRelatedWork W2054992011 @default.
- W1536735543 hasRelatedWork W2060618991 @default.
- W1536735543 hasRelatedWork W2063619316 @default.
- W1536735543 hasRelatedWork W2064416809 @default.
- W1536735543 hasRelatedWork W2153965615 @default.
- W1536735543 hasRelatedWork W2163700154 @default.
- W1536735543 hasRelatedWork W2169225653 @default.
- W1536735543 hasVolume "253" @default.
- W1536735543 isParatext "false" @default.
- W1536735543 isRetracted "false" @default.
- W1536735543 magId "1536735543" @default.
- W1536735543 workType "article" @default.