FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1537211934> ?p ?o ?g. }

• W1537211934 endingPage "1126" @default.
• W1537211934 startingPage "1117" @default.
• W1537211934 abstract "Intrathecal administration of alpha(2)-adrenoceptor agonists produces potent analgesia. This study addressed the subtype of spinal alpha(2)-adrenoceptor responsible for the analgesic effects of i.t. dexmedetomidine and ST-91 in the formalin behavioural model and their effects on primary afferent substance P (SP) release and spinal Fos activation.The analgesic effects of i.t. dexmedetomidine and ST-91 (alpha(2) agonists) were tested on the formalin behavioural model. To determine the subtype of alpha(2)-adrenoceptor involved in the analgesia, i.t. BRL44408 (alpha(2A) antagonist) or ARC239 (alpha(2B/C) antagonist) were given before dexmedetomidine or ST-91. Moreover, the ability of dexmedetomidine and ST-91 to inhibit formalin-induced release of SP from primary afferent terminals was measured by the internalization of neurokinin(1) (NK(1)) receptors. Finally, the effects of dexmedetomidine on formalin-induced Fos expression were assessed in the dorsal horn.Intrathecal administration of dexmedetomidine or ST-91 dose-dependently reduced the formalin-induced paw-flinching behaviour in rats. BRL44408 dose-dependently blocked, whereas ARC239 had no effect on the analgesic actions of dexmedetomidine and ST-91. Dexmedetomidine and ST-91 had no effect on the formalin-induced NK(1) receptor internalization, while morphine significantly reduced the NK(1) receptor internalization. On the other hand, both dexmedetomidine and morphine diminished the formalin-induced Fos activation. The effect of dexmedetomidine on formalin-induced Fos activation was reversed by BRL44408, but not ARC239.These findings suggest that alpha(2A)-adrenoceptors mediate dexmedetomidine and ST-91 analgesia. This effect could be through a mechanism postsynaptic to primary afferent terminals, distinct from that of morphine." @default.
• W1537211934 created "2016-06-24" @default.
• W1537211934 creator A5011682111 @default.
• W1537211934 creator A5014914307 @default.
• W1537211934 creator A5048792774 @default.
• W1537211934 creator A5053454704 @default.
• W1537211934 date "2008-12-01" @default.
• W1537211934 modified "2023-10-14" @default.
• W1537211934 title "Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by α_2A -adrenoceptors: a mechanism of action distinct from morphine" @default.
• W1537211934 cites W1537638589 @default.
• W1537211934 cites W1678824425 @default.
• W1537211934 cites W1799894364 @default.
• W1537211934 cites W1829371640 @default.
• W1537211934 cites W1841227142 @default.
• W1537211934 cites W1903141403 @default.
• W1537211934 cites W1949942852 @default.
• W1537211934 cites W1980830057 @default.
• W1537211934 cites W1988468898 @default.
• W1537211934 cites W1989973534 @default.
• W1537211934 cites W1997662455 @default.
• W1537211934 cites W1999776567 @default.
• W1537211934 cites W2000163046 @default.
• W1537211934 cites W2004251390 @default.
• W1537211934 cites W2007329468 @default.
• W1537211934 cites W2009717522 @default.
• W1537211934 cites W2012877434 @default.
• W1537211934 cites W2019079634 @default.
• W1537211934 cites W2020548112 @default.
• W1537211934 cites W2022936592 @default.
• W1537211934 cites W2027043399 @default.
• W1537211934 cites W2049589290 @default.
• W1537211934 cites W2050714163 @default.
• W1537211934 cites W2055882351 @default.
• W1537211934 cites W2060902782 @default.
• W1537211934 cites W2063077682 @default.
• W1537211934 cites W2065605819 @default.
• W1537211934 cites W2066914942 @default.
• W1537211934 cites W2069380892 @default.
• W1537211934 cites W2077723675 @default.
• W1537211934 cites W2078788661 @default.
• W1537211934 cites W2080967755 @default.
• W1537211934 cites W2090135185 @default.
• W1537211934 cites W2094713497 @default.
• W1537211934 cites W2096535879 @default.
• W1537211934 cites W2105066003 @default.
• W1537211934 cites W2112521537 @default.
• W1537211934 cites W2115172250 @default.
• W1537211934 cites W2118724369 @default.
• W1537211934 cites W2123166542 @default.
• W1537211934 cites W2142699862 @default.
• W1537211934 cites W2150644915 @default.
• W1537211934 cites W2158109323 @default.
• W1537211934 cites W2159658756 @default.
• W1537211934 cites W2171205074 @default.
• W1537211934 cites W2252999163 @default.
• W1537211934 cites W2339469668 @default.
• W1537211934 cites W4205281492 @default.
• W1537211934 cites W4231241402 @default.
• W1537211934 cites W85997367 @default.
• W1537211934 doi "https://doi.org/10.1038/bjp.2008.341" @default.
• W1537211934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2597249" @default.
• W1537211934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18846040" @default.
• W1537211934 hasPublicationYear "2008" @default.
• W1537211934 type Work @default.
• W1537211934 sameAs 1537211934 @default.
• W1537211934 citedByCount "33" @default.
• W1537211934 countsByYear W15372119342012 @default.
• W1537211934 countsByYear W15372119342014 @default.
• W1537211934 countsByYear W15372119342015 @default.
• W1537211934 countsByYear W15372119342016 @default.
• W1537211934 countsByYear W15372119342017 @default.
• W1537211934 countsByYear W15372119342018 @default.
• W1537211934 countsByYear W15372119342019 @default.
• W1537211934 countsByYear W15372119342022 @default.
• W1537211934 countsByYear W15372119342023 @default.
• W1537211934 crossrefType "journal-article" @default.
• W1537211934 hasAuthorship W1537211934A5011682111 @default.
• W1537211934 hasAuthorship W1537211934A5014914307 @default.
• W1537211934 hasAuthorship W1537211934A5048792774 @default.
• W1537211934 hasAuthorship W1537211934A5053454704 @default.
• W1537211934 hasBestOaLocation W15372119342 @default.
• W1537211934 hasConcept C126322002 @default.
• W1537211934 hasConcept C13348194 @default.
• W1537211934 hasConcept C134018914 @default.
• W1537211934 hasConcept C141071460 @default.
• W1537211934 hasConcept C170493617 @default.
• W1537211934 hasConcept C2775944032 @default.
• W1537211934 hasConcept C2776312488 @default.
• W1537211934 hasConcept C2776814716 @default.
• W1537211934 hasConcept C2776885963 @default.
• W1537211934 hasConcept C2777389121 @default.
• W1537211934 hasConcept C2777953023 @default.
• W1537211934 hasConcept C2779520467 @default.
• W1537211934 hasConcept C2780820201 @default.
• W1537211934 hasConcept C2781302539 @default.
• W1537211934 hasConcept C42219234 @default.
• W1537211934 hasConcept C49453240 @default.
• W1537211934 hasConcept C64943373 @default.

• next