Matches in SemOpenAlex for { <https://semopenalex.org/work/W153723573> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W153723573 abstract "Publisher Summary This chapter discusses the effects of isoniazid metabolites on the rate of hepatic microsomal defluorination of volatile fluorinated ether anesthetics. Administration of isoniazid—isonicotinic acid hydrazide—to Fischer 344 rats increases the in vitro metabolism of several substrates of the hepatic mixed function oxidase system. The pattern of catalytic activities differs from that associated with either phenobarital or B-naphthoflavone treatment. The volatile inhalation anesthetics methoxyflurane, enflurane, isoflurane, and sevoflurane are biotransformed to several possible toxic metabolites including inorganic fluoride (F−). High serum concentrations of F− result in vasopressin-resistant polyuric renal insufficiency in rats and man. Enhanced defluorination of these anesthetics is of potential clinical importance. Until recent studies with isoniazid, no drug has been demonstrated to increase the metabolism of the fluorinated ether anesthetics to a significant degree. The chapter describes a study that determines the isoniazid metabolites that are responsible for enhanced anesthetic metabolism in Fischer 344 rats. The rates of hepatic microsomal defluorination were determined for each of the four anesthetic agents following the administration of isonicotinic acid (INA), acetylhydrazine (AcH), hydrazine (H), or saline (S)." @default.
- W153723573 created "2016-06-24" @default.
- W153723573 creator A5013982836 @default.
- W153723573 creator A5072326204 @default.
- W153723573 date "1980-01-01" @default.
- W153723573 modified "2023-10-17" @default.
- W153723573 title "EFFECTS OF ISONIAZID METABOLITES ON THE RATE OF HEPATIC MICROSOMAL DEFLUORINATION OF VOLATILE FLUORINATED ETHER ANESTHETICS" @default.
- W153723573 cites W149868340 @default.
- W153723573 cites W1506043065 @default.
- W153723573 cites W1951469402 @default.
- W153723573 cites W2079875460 @default.
- W153723573 cites W2080425089 @default.
- W153723573 doi "https://doi.org/10.1016/b978-0-12-187702-6.50055-4" @default.
- W153723573 hasPublicationYear "1980" @default.
- W153723573 type Work @default.
- W153723573 sameAs 153723573 @default.
- W153723573 citedByCount "0" @default.
- W153723573 crossrefType "book-chapter" @default.
- W153723573 hasAuthorship W153723573A5013982836 @default.
- W153723573 hasAuthorship W153723573A5072326204 @default.
- W153723573 hasConcept C142724271 @default.
- W153723573 hasConcept C178790620 @default.
- W153723573 hasConcept C185592680 @default.
- W153723573 hasConcept C202751555 @default.
- W153723573 hasConcept C2775998212 @default.
- W153723573 hasConcept C2776359302 @default.
- W153723573 hasConcept C2776932660 @default.
- W153723573 hasConcept C2776967927 @default.
- W153723573 hasConcept C2777854368 @default.
- W153723573 hasConcept C2777858289 @default.
- W153723573 hasConcept C2778162923 @default.
- W153723573 hasConcept C2780407432 @default.
- W153723573 hasConcept C2780526412 @default.
- W153723573 hasConcept C2781069245 @default.
- W153723573 hasConcept C42219234 @default.
- W153723573 hasConcept C55493867 @default.
- W153723573 hasConcept C62231903 @default.
- W153723573 hasConcept C71924100 @default.
- W153723573 hasConcept C87644729 @default.
- W153723573 hasConcept C89311334 @default.
- W153723573 hasConcept C98274493 @default.
- W153723573 hasConceptScore W153723573C142724271 @default.
- W153723573 hasConceptScore W153723573C178790620 @default.
- W153723573 hasConceptScore W153723573C185592680 @default.
- W153723573 hasConceptScore W153723573C202751555 @default.
- W153723573 hasConceptScore W153723573C2775998212 @default.
- W153723573 hasConceptScore W153723573C2776359302 @default.
- W153723573 hasConceptScore W153723573C2776932660 @default.
- W153723573 hasConceptScore W153723573C2776967927 @default.
- W153723573 hasConceptScore W153723573C2777854368 @default.
- W153723573 hasConceptScore W153723573C2777858289 @default.
- W153723573 hasConceptScore W153723573C2778162923 @default.
- W153723573 hasConceptScore W153723573C2780407432 @default.
- W153723573 hasConceptScore W153723573C2780526412 @default.
- W153723573 hasConceptScore W153723573C2781069245 @default.
- W153723573 hasConceptScore W153723573C42219234 @default.
- W153723573 hasConceptScore W153723573C55493867 @default.
- W153723573 hasConceptScore W153723573C62231903 @default.
- W153723573 hasConceptScore W153723573C71924100 @default.
- W153723573 hasConceptScore W153723573C87644729 @default.
- W153723573 hasConceptScore W153723573C89311334 @default.
- W153723573 hasConceptScore W153723573C98274493 @default.
- W153723573 hasLocation W1537235731 @default.
- W153723573 hasOpenAccess W153723573 @default.
- W153723573 hasPrimaryLocation W1537235731 @default.
- W153723573 hasRelatedWork W1530163795 @default.
- W153723573 hasRelatedWork W1912377959 @default.
- W153723573 hasRelatedWork W1966029095 @default.
- W153723573 hasRelatedWork W1971366625 @default.
- W153723573 hasRelatedWork W1988964827 @default.
- W153723573 hasRelatedWork W2020000220 @default.
- W153723573 hasRelatedWork W2022496120 @default.
- W153723573 hasRelatedWork W2027999566 @default.
- W153723573 hasRelatedWork W2032337750 @default.
- W153723573 hasRelatedWork W2033307496 @default.
- W153723573 hasRelatedWork W2034839622 @default.
- W153723573 hasRelatedWork W2055310656 @default.
- W153723573 hasRelatedWork W2055981300 @default.
- W153723573 hasRelatedWork W2061305758 @default.
- W153723573 hasRelatedWork W2122063071 @default.
- W153723573 hasRelatedWork W2151577556 @default.
- W153723573 hasRelatedWork W2414445883 @default.
- W153723573 hasRelatedWork W566605557 @default.
- W153723573 hasRelatedWork W1249889763 @default.
- W153723573 hasRelatedWork W2338753163 @default.
- W153723573 isParatext "false" @default.
- W153723573 isRetracted "false" @default.
- W153723573 magId "153723573" @default.
- W153723573 workType "book-chapter" @default.