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- W1537502716 abstract "With a growing number of applications associated with nanostructures, characterization in-vivo is imperative. Previous MRI studies have described the accumulation of SPION’s in the rat and pig kidneys following intravenous (i.v) injection. Since intra-renal accumulation of SPION’s may lead to acute kidney injury, we sought to assess an array of physiological parameters including renal function following injection of SPION’s. Adult male Wistar rats (n=16) were anaesthetised with an i.p. injection of sodium pentobarbital (60mg/kg bw). Mean arterial pressure (MAP) was continually monitored. Plasma and urine samples were collected over 20 minute clearance periods, two prior to and two following injection of 2mg/kg SPION’s (MF66 or OD15). Plasma and urine were analysed for electrolyte measurements and determination of the glomerular filtration rate (GFR). I.v. injection of both SPION’s led to a significant transient drop in MAP. Glomerular filtration rate (GFR) was not significantly affected following SPION injection, however fractional sodium excretion (FENa) and absolute sodium excretion (UVNa) significantly increased in SPION-treated animals compared to baseline values, (p=0.0313, one-tailed Wilcoxin signed rank test). The mechanisms of this MAP drop and natriuresis is unclear but may involve vasodilator release, e.g. prostaglandins, which oppose the actions of the Renin Angiotensin System. Grant Funding Source: Framework Project 7" @default.
- W1537502716 created "2016-06-24" @default.
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- W1537502716 date "2014-04-01" @default.
- W1537502716 modified "2023-09-26" @default.
- W1537502716 title "Assessment of physiological parameters in the rat following intravenous injection of superparamagnetic iron oxide nanoparticles (SPION’s) (LB730)" @default.
- W1537502716 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb730" @default.
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