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• W1537651127 abstract "Cancer management has experienced an important progress in the last years due to the discovery of new treatments and an improvement in the early detection methods. These improvements have had an important repercussion in patients life span, having an impact in both time and quality life (Berardi et al., 2009). At the same time, knowledge of the specific characteristics of each tumor has led us, in recent times, to be aware of the need of study the unique identity of the cancer (Li & Lai, 2009). For rectal cancer patients, 5-fluorouracil (5-FU)based chemoradiotherapy before total mesorectal excision (TME) is the gold standard treatment for stage II and III (Sauer et al., 2004; Wheeler et al., 2004), but the overall rate of response is still about 46-74% (Wheeler et al., 2004; Chen et al.,1994) Research has focused in the discovery of more specific treatments for each cancer and, at the same time, has tried to identify the particular features of cancer cells with the purpose of design target drugs for these cells in order to avoid affect normal cells. Recently, several studies aim at adding to this regimen several different currently available chemotherapeutics in colon cancer treatment, such as the 5-FU prodrug, capecitabine (Carlomagno et al., 2009; Ugidos et al., 2009), oxaliplatin (Carlomagno et al., 2009), irinotecan (Ugidos et al., 2009), cetuximab (Bertolini et al., 2009) or bevacizumab (Willett et al., 2009). But these treatments are not devoid of adverse effects that could put at risk patients lives due to the treatment itself, so, in these state of affairs,there is a need for identify patients that are going to experience important adverse effects or try to recognize the patients in which the drug benefits will be more than the adverse effects produced; with this purpose, pharmacogenomics and more specific pharmacogenetics studies arise, that so far, have a bright and a dark side." @default.
• W1537651127 created "2016-06-24" @default.
• W1537651127 creator A5013878217 @default.
• W1537651127 creator A5014302880 @default.
• W1537651127 creator A5016992044 @default.
• W1537651127 creator A5055742233 @default.
• W1537651127 creator A5062925890 @default.
• W1537651127 creator A5065928648 @default.
• W1537651127 creator A5074180638 @default.
• W1537651127 creator A5088999057 @default.
• W1537651127 date "2011-10-10" @default.
• W1537651127 modified "2023-09-27" @default.
• W1537651127 title "Role of Tumor Tissue Analysis in Rectal Cancer Pharmacogenetics" @default.
• W1537651127 cites W114710312 @default.
• W1537651127 cites W1484743564 @default.
• W1537651127 cites W1490860457 @default.
• W1537651127 cites W1554772482 @default.
• W1537651127 cites W1831535185 @default.
• W1537651127 cites W1884213330 @default.
• W1537651127 cites W1893723137 @default.
• W1537651127 cites W1965295262 @default.
• W1537651127 cites W1966251853 @default.
• W1537651127 cites W1967971927 @default.
• W1537651127 cites W1975339732 @default.
• W1537651127 cites W1976874797 @default.
• W1537651127 cites W1977439202 @default.
• W1537651127 cites W1977468182 @default.
• W1537651127 cites W1977932650 @default.
• W1537651127 cites W1978307333 @default.
• W1537651127 cites W1978331029 @default.
• W1537651127 cites W1986876550 @default.
• W1537651127 cites W1990363757 @default.
• W1537651127 cites W1990763949 @default.
• W1537651127 cites W2000170100 @default.
• W1537651127 cites W2001337137 @default.
• W1537651127 cites W2010366112 @default.
• W1537651127 cites W2013784882 @default.
• W1537651127 cites W2014181699 @default.
• W1537651127 cites W2014591254 @default.
• W1537651127 cites W2016747856 @default.
• W1537651127 cites W2017479895 @default.
• W1537651127 cites W2023240259 @default.
• W1537651127 cites W2025199554 @default.
• W1537651127 cites W2026735682 @default.
• W1537651127 cites W2028392042 @default.
• W1537651127 cites W2028395388 @default.
• W1537651127 cites W2029348349 @default.
• W1537651127 cites W2035486075 @default.
• W1537651127 cites W2038965915 @default.
• W1537651127 cites W2039356362 @default.
• W1537651127 cites W2044000184 @default.
• W1537651127 cites W2047783423 @default.
• W1537651127 cites W2049355372 @default.
• W1537651127 cites W2052560320 @default.
• W1537651127 cites W2055176101 @default.
• W1537651127 cites W2058203160 @default.
• W1537651127 cites W2059300459 @default.
• W1537651127 cites W2065829703 @default.
• W1537651127 cites W2066847809 @default.
• W1537651127 cites W2067470404 @default.
• W1537651127 cites W2071551577 @default.
• W1537651127 cites W2073438113 @default.
• W1537651127 cites W2074719020 @default.
• W1537651127 cites W2076868701 @default.
• W1537651127 cites W2080067076 @default.
• W1537651127 cites W2085218834 @default.
• W1537651127 cites W2090981065 @default.
• W1537651127 cites W2095822339 @default.
• W1537651127 cites W2096136751 @default.
• W1537651127 cites W2099154608 @default.
• W1537651127 cites W2106515413 @default.
• W1537651127 cites W2122340450 @default.
• W1537651127 cites W2123794181 @default.
• W1537651127 cites W2125173168 @default.
• W1537651127 cites W2125452425 @default.
• W1537651127 cites W2126172213 @default.
• W1537651127 cites W2127961360 @default.
• W1537651127 cites W2129684203 @default.
• W1537651127 cites W2130392703 @default.
• W1537651127 cites W2139586102 @default.
• W1537651127 cites W2141254782 @default.
• W1537651127 cites W2141878889 @default.
• W1537651127 cites W2142167347 @default.
• W1537651127 cites W2146590101 @default.
• W1537651127 cites W2147354890 @default.
• W1537651127 cites W2151486690 @default.
• W1537651127 cites W2154745425 @default.
• W1537651127 cites W2155118005 @default.
• W1537651127 cites W2155395660 @default.
• W1537651127 cites W2155535878 @default.
• W1537651127 cites W2157004858 @default.
• W1537651127 cites W2160624529 @default.
• W1537651127 cites W2160721100 @default.
• W1537651127 cites W2163754679 @default.
• W1537651127 cites W2165715420 @default.
• W1537651127 cites W2165894292 @default.
• W1537651127 cites W2167064353 @default.
• W1537651127 cites W2169637630 @default.
• W1537651127 cites W2310743441 @default.
• W1537651127 cites W277398450 @default.

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