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• W1537762010 abstract "A new column chromatographic procedure for the separation of different hemoglobin fractions using DEAE-cellulose as adsorbent is described. Except for fetal hemoglobin the elution rates of the hemoglobin components were found to be in accordance with the differences in electrophoretic points. The elution rates, as measured by their elution volumes, are within certain limits independent of the total amount of Hb chromatographed; the elution rates were greatly influenced by the initial pH values of the adsorbent. Examples of hemoglobin separations are presented for cases with the following Hb-abnormalities: AS, AC, AJ (Georgia), SS, SC, normal cord blood, cord blood samples from babies heterozygous for Hb-S and for Hb-C, cord blood sample with the abnormal Bart's Hb, Thalassemia minor and major, Hb-E-thalassemia disease, persistent high Hb-F abnormality, persistent high Hb-F abnormality combined with Hb-S, Hb-B2 trait, Hb-B2 trait associated with thalassemia, the Hb “Lepore” abnormality, and a case with an unknown abnormal minor Hb-component. Since small amounts of Hb-F are generally eluted with the minor Hb-A1 fraction, application of an alkali denaturation method to this isolated fraction offered a new and fairly accurate procedure for the determination of small amounts of Hb-F. Applications to cases with thalassemia minor and the Hb “Lepore” abnormality have been presented. The quantitative data obtained with the procedure were in agreement with the results obtained by starch block electrophoresis and carboxymethylcellulose chromatography. It was emphasized that the method was of particular use for the minor Hb fractions: A2, B2, Lepore and of small amounts of Hb-F. The heterogeneity of the hemoglobins of normal adults, sickle cell anemia patients, and cord blood samples as observed by DEAE-cellulose chromatography was found to be closely related to those found by electrophoretic methods and by CM_cellulose chromatography. The DEAE-cellulose chromatography was found of great use for the preparation of large quantities of pure Hb-fractions: examples for Hb-A2 and Hb-Lepore have been presented." @default.
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• W1537762010 date "1962-01-01" @default.
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• W1537762010 title "Studies on the heterogeneity of hemoglobin" @default.
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• W1537762010 doi "https://doi.org/10.1016/s0021-9673(01)86397-4" @default.
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