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- W1537776040 abstract "This chapter describes the use of OCT4 immunohistochemistry (IHC) to aid in the diagnosis of dysgerminoma and the exclusion of tumors that may mimic its appearance, but have different biologic and therapeutic implications. OCT4 is a POU-domain, octamerbinding transcription factor, expressed in both mouse and human embryonic stem and germ cells. This protein is found in pluripotent cells of the embryo, primordial germ cells, and oocytes. Ovarian dysgerminomas may co-exist, with other malignant germ cell tumor types, and the prognosis of mixed germ cell tumors is dependent on the most aggressive germ cell element. Dysgerminoma may originate from the primordial germ cells that migrate to the ovary, from the wall of the yolk sac, during early embryogenesis. OCT4 IHC proves to be a useful diagnostic adjunct for the identification of primary ovarian dysgerminoma and gonadoblastoma. OCT4 may aid in the detection of small foci of metastatic dysgerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors in the ovary." @default.
- W1537776040 created "2016-06-24" @default.
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- W1537776040 date "2005-01-01" @default.
- W1537776040 modified "2023-09-27" @default.
- W1537776040 title "23 Role of Immunohistochemical Expression of OCT4 in Ovarian Dysgerminoma" @default.
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- W1537776040 doi "https://doi.org/10.1016/s1874-5784(05)80109-6" @default.
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