Matches in SemOpenAlex for { <https://semopenalex.org/work/W1538045582> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1538045582 endingPage "858" @default.
- W1538045582 startingPage "853" @default.
- W1538045582 abstract "Abstract Expression of p70/75 IL-2-binding molecules and their functional roles in induction of Ig secretion by IL-2 were examined in human B cells. IL-2, at high concentrations induced higher levels of Ig secretion in Staphylococcus aureus strain Cowan I (SAC)-activated B cells than at low concentrations. About 50% of SAC-activated B cells, lacking Tac antigen, were also responsive to Ig secretion by IL-2, although the required dose of IL-2 was higher than that for Tac-positive B cells. H-31 antibody which recognizes Tac antigen did not inhibit the induction of Ig secretion by high concentrations of IL-2 in both Tac-negative and Tac-positive B cells, suggesting that IL-2 might induce Ig secretion through a receptor distinct from Tac antigens. In contrast, IL-2 was ineffective in the absence of SAC stimulation even at high concentrations. Upon analysis by SDS-PAGE, p70/75 IL-2-binding molecules were detected on Tac-negative SAC-activated B cells. Similar IL-2-binding molecules distinct from Tac antigen (p55) were detected in both Tac-positive B and T cells. However, neither p55 nor p70/75 IL-2-binding molecules could be detected in the absence of SAC stimulation. These observations suggest that p70/75 IL-2 binding molecules are induced in human B-cells in the presence or absence of Tac antigen by SAC stimulation and these determinants play an important function in the transduction of IL-2 associated signal for B cell differentiation." @default.
- W1538045582 created "2016-06-24" @default.
- W1538045582 creator A5007732408 @default.
- W1538045582 creator A5018262222 @default.
- W1538045582 creator A5034689721 @default.
- W1538045582 creator A5044287074 @default.
- W1538045582 date "1988-02-01" @default.
- W1538045582 modified "2023-10-12" @default.
- W1538045582 title "Expression and the functional role of a p70/75 interleukin 2-binding molecule in human B cell." @default.
- W1538045582 doi "https://doi.org/10.4049/jimmunol.140.3.853" @default.
- W1538045582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2828472" @default.
- W1538045582 hasPublicationYear "1988" @default.
- W1538045582 type Work @default.
- W1538045582 sameAs 1538045582 @default.
- W1538045582 citedByCount "22" @default.
- W1538045582 crossrefType "journal-article" @default.
- W1538045582 hasAuthorship W1538045582A5007732408 @default.
- W1538045582 hasAuthorship W1538045582A5018262222 @default.
- W1538045582 hasAuthorship W1538045582A5034689721 @default.
- W1538045582 hasAuthorship W1538045582A5044287074 @default.
- W1538045582 hasBestOaLocation W15380455821 @default.
- W1538045582 hasConcept C134018914 @default.
- W1538045582 hasConcept C147483822 @default.
- W1538045582 hasConcept C153911025 @default.
- W1538045582 hasConcept C159654299 @default.
- W1538045582 hasConcept C170493617 @default.
- W1538045582 hasConcept C203014093 @default.
- W1538045582 hasConcept C24998067 @default.
- W1538045582 hasConcept C2776090121 @default.
- W1538045582 hasConcept C49039625 @default.
- W1538045582 hasConcept C55493867 @default.
- W1538045582 hasConcept C86803240 @default.
- W1538045582 hasConcept C8891405 @default.
- W1538045582 hasConcept C95444343 @default.
- W1538045582 hasConceptScore W1538045582C134018914 @default.
- W1538045582 hasConceptScore W1538045582C147483822 @default.
- W1538045582 hasConceptScore W1538045582C153911025 @default.
- W1538045582 hasConceptScore W1538045582C159654299 @default.
- W1538045582 hasConceptScore W1538045582C170493617 @default.
- W1538045582 hasConceptScore W1538045582C203014093 @default.
- W1538045582 hasConceptScore W1538045582C24998067 @default.
- W1538045582 hasConceptScore W1538045582C2776090121 @default.
- W1538045582 hasConceptScore W1538045582C49039625 @default.
- W1538045582 hasConceptScore W1538045582C55493867 @default.
- W1538045582 hasConceptScore W1538045582C86803240 @default.
- W1538045582 hasConceptScore W1538045582C8891405 @default.
- W1538045582 hasConceptScore W1538045582C95444343 @default.
- W1538045582 hasIssue "3" @default.
- W1538045582 hasLocation W15380455821 @default.
- W1538045582 hasLocation W15380455822 @default.
- W1538045582 hasOpenAccess W1538045582 @default.
- W1538045582 hasPrimaryLocation W15380455821 @default.
- W1538045582 hasRelatedWork W1484614058 @default.
- W1538045582 hasRelatedWork W1484759019 @default.
- W1538045582 hasRelatedWork W1972479046 @default.
- W1538045582 hasRelatedWork W2054816609 @default.
- W1538045582 hasRelatedWork W2063143669 @default.
- W1538045582 hasRelatedWork W2119474279 @default.
- W1538045582 hasRelatedWork W2150135081 @default.
- W1538045582 hasRelatedWork W2154839605 @default.
- W1538045582 hasRelatedWork W1926304844 @default.
- W1538045582 hasRelatedWork W2154571754 @default.
- W1538045582 hasVolume "140" @default.
- W1538045582 isParatext "false" @default.
- W1538045582 isRetracted "false" @default.
- W1538045582 magId "1538045582" @default.
- W1538045582 workType "article" @default.