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• W153820199 abstract "This chapter describes the rate of acclimatization to chronic hypercapnia in man. It presents a series of experiments that were carried out to study extensively the rate of respiratory acclimatization to chronic hypercapnia in normal man. In the first experiment, four subjects were exposed to an ambient Pco2 of 30 mmHg for 11 days. In the second experiment, four different subjects were exposed to the same ambient PCO2 for 5 days. The third experiment consisted of a 30-day exposure of four additional subjects to an ambient Pco2 of 21 mmHg. Each experiment was designed to obtain repeated measurements of ventilation and to obtain acid–base indices of arterial blood and lumbar cerebrospinal fluid during hypercapnia. Comparison of the close agreement of the Paco2-ventilation response curves during CO2 exposure with the much wider range of the arterial pH–ventilation response curves provides additional evidence that respiration during acclimatization to prolonged hypercapnia is predominantly controlled by central chemoreceptors, which are not directly influenced by changes in arterial pH. The apparent lack of a change in the ventilatory response slope to increased Paco2 or [H+] does not support the concept that reactivity of the respiratory control centers is diminished during prolonged hypercapnia." @default.
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• W153820199 date "1971-01-01" @default.
• W153820199 modified "2023-10-18" @default.
• W153820199 title "RATE OF ACCLIMATIZATION TO CHRONIC HYPERCAPNIA IN MAN" @default.
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• W153820199 doi "https://doi.org/10.1016/b978-0-12-434750-2.50052-6" @default.
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