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- W1538220119 endingPage "1409" @default.
- W1538220119 startingPage "1389" @default.
- W1538220119 abstract "In the early 1990s, breakthrough discoveries on the genetics of Alzheimer’s disease led to the identification of missense mutations in the amyloid‐β precursor protein gene. Research findings quickly followed, giving insights into molecular pathogenesis and possibilities for the development of new types of animal models. The complete toolbox of transgenic techniques, including pronuclear oocyte injection and homologous recombination, has been applied in the Alzheimer’s disease field, to produce overexpressors, knockouts, knockins and regulatable transgenics. Transgenic models have dramatically advanced our understanding of pathogenic mechanisms and allowed therapeutic approaches to be tested. Following a brief introduction to Alzheimer’s disease, various nontransgenic and transgenic animal models are described in terms of their values and limitations with respect to pathogenic, therapeutic and functional understandings of the human disease." @default.
- W1538220119 created "2016-06-24" @default.
- W1538220119 creator A5006377510 @default.
- W1538220119 creator A5018345023 @default.
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- W1538220119 creator A5035867722 @default.
- W1538220119 creator A5054109471 @default.
- W1538220119 creator A5077335871 @default.
- W1538220119 date "2010-02-24" @default.
- W1538220119 modified "2023-10-18" @default.
- W1538220119 title "Animal models of amyloid-β-related pathologies in Alzheimer’s disease" @default.
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