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• W1538327476 endingPage "619" @default.
• W1538327476 startingPage "609" @default.
• W1538327476 abstract "Semi-conserved exon boundaries in members of the CACNA1 gene family result in recurring pre-mRNA splicing patterns. The resulting variations in the encoded pore-forming subunit of the voltage-gated calcium channel affect functionally significant regions, such as the vicinity of the voltage-sensing S4 segments or the intracellular loops that are important for protein interaction. In addition to generating functional diversity, RNA splicing regulates the quantitative expression of other splice isoforms of the same gene by producing transcripts with premature stop codons which encode two-domain or three-domain channels. An overview of some of the known splice isoforms of the alpha(1) calcium channel subunits and their significance is given." @default.
• W1538327476 created "2016-06-24" @default.
• W1538327476 creator A5045210310 @default.
• W1538327476 creator A5090322200 @default.
• W1538327476 date "2004-02-01" @default.
• W1538327476 modified "2023-10-17" @default.
• W1538327476 title "The impact of splice isoforms on voltage-gated calcium channel α₁subunits" @default.
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