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- W1538470262 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064473 Tumor metastasis is the dominant cause of death in cancer patients, including oral tongue squamous cell carcinoma (SCC) patients. However, the molecular and cellular mechanisms underlying tumor metastasis are still elusive. The identification of molecular markers associated with the metastatic process would help to understand biological mechanisms and facilitate the development of therapeutic interventions for oral tongue cancer patients. We performed global gene expression profiling on 11 lymph node metastatic (pN+) and 14 non-metastatic negative (pN-) SCC samples of tongue, and the matching normal tissues. Using stringent statistical criteria (fold difference >2, and p 90% accuracy. These analyses also generated a second gene list that can provide superb classification power for extracapsular spread (ECS). ECS is considered as the most reliable clinical predictor of poor treatment outcomes of metastatic squamous cell carcinoma of the head and neck to regional lymph nodes. expression profiling capable of predicting ECS phenotype has not been reported previously, so these results have high substantive significance. This work is supported in part by K22 DE014847, RO3 DE016569, RO3 CA114688, and a TRDRP grant 13KT-0028 (Zhou), Foundation de France grant (Temam), P01 CA106451 Project 3 (Mao), R01 DE015970 (Wong)." @default.
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- W1538470262 date "2006-04-15" @default.
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- W1538470262 title "Global expression based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma" @default.
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