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- W1538471562 abstract "A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control experiment involving a conformationally locked 3-substituted 4-bromo-tert-butyl cyclohexane ring proceeded with essentially complete stereoselectivity." @default.
- W1538471562 created "2016-06-24" @default.
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- W1538471562 date "2014-05-27" @default.
- W1538471562 modified "2023-10-10" @default.
- W1538471562 title "Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation" @default.
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- W1538471562 doi "https://doi.org/10.1002/ejoc.201402108" @default.
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