Matches in SemOpenAlex for { <https://semopenalex.org/work/W1538603016> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1538603016 endingPage "4299" @default.
- W1538603016 startingPage "4292" @default.
- W1538603016 abstract "We have evaluated the relationship between the neuronal myc gene (NMYC) and class I major histocompatibility complex (MHC) expression in human neuroblastoma (NB) tumor cell lines. Class I MHC surface Ag expression in NB cell lines varied from nearly undetectable to levels nearly as high as in a lymphoblastoid cell line. Class I MHC mRNA levels in NMYC-amplified NB cell lines were lower than levels observed in single copy NMYC NB cell lines. However, considerable variation in class I MHC surface Ag and mRNA expression was evident in NMYC-amplified cell lines. To determine directly whether NMYC might modulate class I MHC expression in NB, we transfected a plasmid containing a recombinant NMYC gene into two tumor cell lines derived from a NB and a related neuroepithelioma tumor. Constitutive overexpression of the recombinant NMYC gene produced no consistent change in class I MHC surface Ag or mRNA levels. To determine whether class I MHC expression might be developmentally regulated in adrenal medullary cells, the precursor cells of adrenal NB tumors, beta 2-microglobulin expression was measured in fetal and adult adrenal glands. beta 2-Microglobulin expression was not evident in the neuroblasts of a 24-wk-old fetal adrenal gland, whereas beta 2-microglobulin expression was present in the adult adrenal medulla. These data suggest that variation in class I MHC expression among NB cells may reflect the developmental stage at which neuroblasts were arrested during tumorigenesis." @default.
- W1538603016 created "2016-06-24" @default.
- W1538603016 creator A5005300334 @default.
- W1538603016 creator A5015648461 @default.
- W1538603016 creator A5047177507 @default.
- W1538603016 creator A5065198906 @default.
- W1538603016 creator A5074373621 @default.
- W1538603016 date "1989-12-15" @default.
- W1538603016 modified "2023-10-18" @default.
- W1538603016 title "Expression of class I histocompatibility antigens in neuroectodermal tumors is independent of the expression of a transfected neuroblastoma myc gene." @default.
- W1538603016 doi "https://doi.org/10.4049/jimmunol.143.12.4292" @default.
- W1538603016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2687378" @default.
- W1538603016 hasPublicationYear "1989" @default.
- W1538603016 type Work @default.
- W1538603016 sameAs 1538603016 @default.
- W1538603016 citedByCount "20" @default.
- W1538603016 countsByYear W15386030162012 @default.
- W1538603016 crossrefType "journal-article" @default.
- W1538603016 hasAuthorship W1538603016A5005300334 @default.
- W1538603016 hasAuthorship W1538603016A5015648461 @default.
- W1538603016 hasAuthorship W1538603016A5047177507 @default.
- W1538603016 hasAuthorship W1538603016A5065198906 @default.
- W1538603016 hasAuthorship W1538603016A5074373621 @default.
- W1538603016 hasBestOaLocation W15386030161 @default.
- W1538603016 hasConcept C104317684 @default.
- W1538603016 hasConcept C134018914 @default.
- W1538603016 hasConcept C147483822 @default.
- W1538603016 hasConcept C150194340 @default.
- W1538603016 hasConcept C153911025 @default.
- W1538603016 hasConcept C170627219 @default.
- W1538603016 hasConcept C203014093 @default.
- W1538603016 hasConcept C207936829 @default.
- W1538603016 hasConcept C21957315 @default.
- W1538603016 hasConcept C2775894120 @default.
- W1538603016 hasConcept C2776715637 @default.
- W1538603016 hasConcept C2777597313 @default.
- W1538603016 hasConcept C39961270 @default.
- W1538603016 hasConcept C4746552 @default.
- W1538603016 hasConcept C502942594 @default.
- W1538603016 hasConcept C54009773 @default.
- W1538603016 hasConcept C54355233 @default.
- W1538603016 hasConcept C81885089 @default.
- W1538603016 hasConcept C86803240 @default.
- W1538603016 hasConcept C95444343 @default.
- W1538603016 hasConceptScore W1538603016C104317684 @default.
- W1538603016 hasConceptScore W1538603016C134018914 @default.
- W1538603016 hasConceptScore W1538603016C147483822 @default.
- W1538603016 hasConceptScore W1538603016C150194340 @default.
- W1538603016 hasConceptScore W1538603016C153911025 @default.
- W1538603016 hasConceptScore W1538603016C170627219 @default.
- W1538603016 hasConceptScore W1538603016C203014093 @default.
- W1538603016 hasConceptScore W1538603016C207936829 @default.
- W1538603016 hasConceptScore W1538603016C21957315 @default.
- W1538603016 hasConceptScore W1538603016C2775894120 @default.
- W1538603016 hasConceptScore W1538603016C2776715637 @default.
- W1538603016 hasConceptScore W1538603016C2777597313 @default.
- W1538603016 hasConceptScore W1538603016C39961270 @default.
- W1538603016 hasConceptScore W1538603016C4746552 @default.
- W1538603016 hasConceptScore W1538603016C502942594 @default.
- W1538603016 hasConceptScore W1538603016C54009773 @default.
- W1538603016 hasConceptScore W1538603016C54355233 @default.
- W1538603016 hasConceptScore W1538603016C81885089 @default.
- W1538603016 hasConceptScore W1538603016C86803240 @default.
- W1538603016 hasConceptScore W1538603016C95444343 @default.
- W1538603016 hasIssue "12" @default.
- W1538603016 hasLocation W15386030161 @default.
- W1538603016 hasLocation W15386030162 @default.
- W1538603016 hasOpenAccess W1538603016 @default.
- W1538603016 hasPrimaryLocation W15386030161 @default.
- W1538603016 hasRelatedWork W1538603016 @default.
- W1538603016 hasRelatedWork W1602195057 @default.
- W1538603016 hasRelatedWork W1963851565 @default.
- W1538603016 hasRelatedWork W1968341723 @default.
- W1538603016 hasRelatedWork W2047799019 @default.
- W1538603016 hasRelatedWork W2052145250 @default.
- W1538603016 hasRelatedWork W2154598572 @default.
- W1538603016 hasRelatedWork W2275463668 @default.
- W1538603016 hasRelatedWork W2407749907 @default.
- W1538603016 hasRelatedWork W4249149539 @default.
- W1538603016 hasVolume "143" @default.
- W1538603016 isParatext "false" @default.
- W1538603016 isRetracted "false" @default.
- W1538603016 magId "1538603016" @default.
- W1538603016 workType "article" @default.