FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1538852005> ?p ?o ?g. }

• W1538852005 endingPage "433" @default.
• W1538852005 startingPage "433" @default.
• W1538852005 abstract "Andrew Moore Editor-in-Chief In this issue, Solé et al. 1 describe a model of a cancer cell as a reduced genetic network operating close to instability: instability that could be exploited by future anti-cancer therapies. Genome reduction during the evolution of cancer within its host is a principal concept that is explored in this article. The key idea is captured in the following sentence, which frames cancer in the context of a unicellular species that has forsaken the intercellular organizing principles of the host organism to go it alone as an independent – and therefore highly resourceful (robust) – agent in an unpredictable (noisy) environment: “More importantly, the loss of intercellular organization suggests an interesting scenario: a reduced cellular complexity that could be mapped into a minimal set of interconnected molecular components operating in a robust way under highly noisy conditions.” It strikes me that another interesting correlate of this concept is that the core network is one that any cell needs to survive (vital housekeeping functions), and that the variations around this core are similar to the metagenomics of bacteria, i.e. highly environment-/niche-dependent. One could, therefore, define the metagenomics of cancer to be the study of genes that respond to the microenvironment. Because the microenvironment is so important for cancer development and progression, cancer cells probably explore this microenvironment, and one would see the traces of that in the genome - specifically the genome that is more peripheral to the stable - minimal - core necessary for survival and maximizing proliferation. Where Solé et al. write “Removable items would include most components related to sensing environmental signals, the preservation of genome integrity, and replication checkpoints.” we might imagine that the cells rather switch from networks that respond to signals from neigbouring cells, or the host as a whole, to networks optimized to “exploit” or manipulate the resources of the host and be sensitive to their fluctuations; stimulation of angiogenesis might well be such an example. If bacteria thrive in certain environments via metagenomic adaptations, and if cancer cells are reminiscent of unicellular organisms, we might expect them to undergo quite specific metagenomic adaptations in response to their microenvironment, i.e. enabling them better to profit from it – or manipulate it. This leads to an interesting paradigmatic concept in my mind: superficially, the malignant cancer cell seems to be a riot of mutations, translocations, duplications, aneuploidy etc.; however, in terms of the way in which the genome is “used” it would appear that certain parts are just shut down because the cell will never “need” them again. If one subscribes to the notion of cancer being the enactment of an evolutionarily ancient program for proliferation 2, could it be that the cancer cell permits all the parts of the genome necessary for construction of a complex multicellular organism to disintegrate or be permanently silenced? I think that one of the largest paradigm shifts that emerges from Solé et al. is the concept of the cancer cell managing its genome in a highly efficient and “creative” way. This is very far removed from the concept of cancer as a disease of rampant random mutation, genomic dysregulation, and havoc. Cancer is a disease, alright, but the cancer cell's genome is anything but “sick”. It could be that such a change in perspective on cancer will yield important new insights into its biology and treatment. Andrew Moore Editor-in-Chief" @default.
• W1538852005 created "2016-06-24" @default.
• W1538852005 creator A5050606301 @default.
• W1538852005 date "2014-04-09" @default.
• W1538852005 modified "2023-10-18" @default.
• W1538852005 title "Cancer: A disease of highly efficient and creative genome management?" @default.
• W1538852005 cites W1877657124 @default.
• W1538852005 cites W2111850731 @default.
• W1538852005 doi "https://doi.org/10.1002/bies.201400051" @default.
• W1538852005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24723410" @default.
• W1538852005 hasPublicationYear "2014" @default.
• W1538852005 type Work @default.
• W1538852005 sameAs 1538852005 @default.
• W1538852005 citedByCount "0" @default.
• W1538852005 crossrefType "journal-article" @default.
• W1538852005 hasAuthorship W1538852005A5050606301 @default.
• W1538852005 hasBestOaLocation W15388520051 @default.
• W1538852005 hasConcept C104317684 @default.
• W1538852005 hasConcept C121608353 @default.
• W1538852005 hasConcept C137858568 @default.
• W1538852005 hasConcept C141231307 @default.
• W1538852005 hasConcept C143425029 @default.
• W1538852005 hasConcept C151730666 @default.
• W1538852005 hasConcept C153991713 @default.
• W1538852005 hasConcept C178169997 @default.
• W1538852005 hasConcept C18903297 @default.
• W1538852005 hasConcept C2779343474 @default.
• W1538852005 hasConcept C54355233 @default.
• W1538852005 hasConcept C552990157 @default.
• W1538852005 hasConcept C70721500 @default.
• W1538852005 hasConcept C86803240 @default.
• W1538852005 hasConcept C96232424 @default.
• W1538852005 hasConceptScore W1538852005C104317684 @default.
• W1538852005 hasConceptScore W1538852005C121608353 @default.
• W1538852005 hasConceptScore W1538852005C137858568 @default.
• W1538852005 hasConceptScore W1538852005C141231307 @default.
• W1538852005 hasConceptScore W1538852005C143425029 @default.
• W1538852005 hasConceptScore W1538852005C151730666 @default.
• W1538852005 hasConceptScore W1538852005C153991713 @default.
• W1538852005 hasConceptScore W1538852005C178169997 @default.
• W1538852005 hasConceptScore W1538852005C18903297 @default.
• W1538852005 hasConceptScore W1538852005C2779343474 @default.
• W1538852005 hasConceptScore W1538852005C54355233 @default.
• W1538852005 hasConceptScore W1538852005C552990157 @default.
• W1538852005 hasConceptScore W1538852005C70721500 @default.
• W1538852005 hasConceptScore W1538852005C86803240 @default.
• W1538852005 hasConceptScore W1538852005C96232424 @default.
• W1538852005 hasIssue "5" @default.
• W1538852005 hasLocation W15388520051 @default.
• W1538852005 hasLocation W15388520052 @default.
• W1538852005 hasOpenAccess W1538852005 @default.
• W1538852005 hasPrimaryLocation W15388520051 @default.
• W1538852005 hasRelatedWork W1422966172 @default.
• W1538852005 hasRelatedWork W1531420823 @default.
• W1538852005 hasRelatedWork W1994927702 @default.
• W1538852005 hasRelatedWork W2037746381 @default.
• W1538852005 hasRelatedWork W2048159451 @default.
• W1538852005 hasRelatedWork W2144002609 @default.
• W1538852005 hasRelatedWork W2617489830 @default.
• W1538852005 hasRelatedWork W2734829443 @default.
• W1538852005 hasRelatedWork W4220940334 @default.
• W1538852005 hasRelatedWork W4285823231 @default.
• W1538852005 hasVolume "36" @default.
• W1538852005 isParatext "false" @default.
• W1538852005 isRetracted "false" @default.
• W1538852005 magId "1538852005" @default.
• W1538852005 workType "article" @default.