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- W1538860180 abstract "The main aim of present work was to prepare solid dispersion of poorly water soluble drug Gliclazide to enhanceits in-vitro dissolution rate and aqueous solubility of drug. Gliclazide is a second generation of hypoglycemic sulfonylurea. The major drawback in the therapeutic application and efficacy of Gliclazide as oral dosage forms is its very lowaqueous solubility because of its hydrophobic nature. It has short biological half-life, small dose (30-80 mg) hencesuitable for solid dispersion and sustained release formulation. In present study, polyethylene glycol 6000 and PVP K-30were selected as carrier because of their chemical and pharmacological inertness. Polyethylene glycol 6000 and PVP K-30 by virtue of their water solubility leads to high degree of solubilization of poorly soluble drug. After comparing thesolubility and dissolution profiles of various solid dispersions, it was observed that solid dispersion such as SDPEG ½ orSDPVP ½ gave desired dissolution profile of Gliclazide (more than 80% release in first 120 min). In-vitro dissolutionstudies also revealed that SDPVP K-30 ½ has shown less percentage of drug release from tablet for first two to threehours than SDPEG ½. It may due to binding effect of PVP K-30.KEY WORDS: Gliclazide, Poorly water soluble, In-vitro dissolution, solid dispersion, Matrix tablet" @default.
- W1538860180 created "2016-06-24" @default.
- W1538860180 creator A5010407596 @default.
- W1538860180 date "2013-06-24" @default.
- W1538860180 modified "2023-09-24" @default.
- W1538860180 title "DEVELOPMENT OF SUSTAINED RELEASE DOSAGE FORM OF GLICLAZIDE" @default.
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