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• W1538860881 abstract "1 The regulation of renin secretion is mediated by way of adrenoceptors. The role of alpha-adrenoceptors remains controversial, whereas it is generally accepted that activation of beta-adrenoceptors stimulates renin and their blockade suppresses renin. 2 Although experimental renin regulation appears to be a beta 2-receptor function, clinical studies suggest that in man it is a beta 1 effect. 3 beta-Adrenoceptor-blocking agents are effective antihypertensive agents, but have variable effects on renin secretion; this variability may be attributable to different degrees of instrinsic partial beta-agonistic activity and/or different receptor or organ selectivity of various compounds. 4 Antihypertensive effectiveness seems unrelated in magnitude or timing to the baseline levels or the changes of plasma renin activity for the majority of beta-adrenoceptor-blocking drugs." @default.
• W1538860881 created "2016-06-24" @default.
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• W1538860881 date "1979-01-01" @default.
• W1538860881 modified "2023-09-23" @default.
• W1538860881 title "Antihypertensive action of beta-adrenoceptor blockade and the renin-angiotensin system." @default.
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• W1538860881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1429320" @default.
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