Matches in SemOpenAlex for { <https://semopenalex.org/work/W1538863617> ?p ?o ?g. }
- W1538863617 endingPage "916" @default.
- W1538863617 startingPage "906" @default.
- W1538863617 abstract "This study sought to determine the risk versus benefit ratio of an early aggressive (EA) approach in elderly patients with non–ST-segment elevation acute coronary syndromes (NSTEACS). Elderly patients have been scarcely represented in trials comparing treatment strategies in NSTEACS. A total of 313 patients ≥75 years of age (mean 82 years) with NSTEACS within 48 h from qualifying symptoms were randomly allocated to an EA strategy (coronary angiography and, when indicated, revascularization within 72 h) or an initially conservative (IC) strategy (angiography and revascularization only for recurrent ischemia). The primary endpoint was the composite of death, myocardial infarction, disabling stroke, and repeat hospital stay for cardiovascular causes or severe bleeding within 1 year. During admission, 88% of the patients in the EA group underwent angiography (55% revascularization), compared with 29% (23% revascularization) in the IC group. The primary outcome occurred in 43 patients (27.9%) in the EA group and 55 (34.6%) in the IC group (hazard ratio [HR]: 0.80; 95% confidence interval [CI]: 0.53 to 1.19; p = 0.26). The rates of mortality (HR: 0.87; 95% CI: 0.49 to 1.56), myocardial infarction (HR: 0.67; 95% CI: 0.33 to 1.36), and repeat hospital stay (HR: 0.81; 95% CI: 0.45 to 1.46) did not differ between groups. The primary endpoint was significantly reduced in patients with elevated troponin on admission (HR: 0.43; 95% CI: 0.23 to 0.80), but not in those with normal troponin (HR: 1.67; 95% CI: 0.75 to 3.70; p for interaction = 0.03). The present study does not allow a definite conclusion about the benefit of an EA approach when applied systematically among elderly patients with NSTEACS. The finding of a significant interaction for the treatment effect according to troponin status at baseline should be confirmed in a larger size trial. (Italian Elderly ACS Study; NCT00510185)" @default.
- W1538863617 created "2016-06-24" @default.
- W1538863617 creator A5001027053 @default.
- W1538863617 creator A5003180371 @default.
- W1538863617 creator A5035216830 @default.
- W1538863617 creator A5042435666 @default.
- W1538863617 creator A5046097365 @default.
- W1538863617 creator A5050537243 @default.
- W1538863617 creator A5052130375 @default.
- W1538863617 creator A5053270731 @default.
- W1538863617 creator A5054453490 @default.
- W1538863617 creator A5055861900 @default.
- W1538863617 creator A5056134091 @default.
- W1538863617 creator A5061510316 @default.
- W1538863617 creator A5068102973 @default.
- W1538863617 creator A5073232153 @default.
- W1538863617 creator A5074605462 @default.
- W1538863617 creator A5076374312 @default.
- W1538863617 creator A5076817668 @default.
- W1538863617 creator A5077732078 @default.
- W1538863617 creator A5087456355 @default.
- W1538863617 date "2012-09-01" @default.
- W1538863617 modified "2023-10-02" @default.
- W1538863617 title "Early Aggressive Versus Initially Conservative Treatment in Elderly Patients With Non–ST-Segment Elevation Acute Coronary Syndrome" @default.
- W1538863617 cites W189220612 @default.
- W1538863617 cites W1967779018 @default.
- W1538863617 cites W1979038033 @default.
- W1538863617 cites W1987887000 @default.
- W1538863617 cites W2000165789 @default.
- W1538863617 cites W2011047627 @default.
- W1538863617 cites W2011112862 @default.
- W1538863617 cites W2034185700 @default.
- W1538863617 cites W2077732062 @default.
- W1538863617 cites W2096002945 @default.
- W1538863617 cites W2096807893 @default.
- W1538863617 cites W2098044998 @default.
- W1538863617 cites W2105308779 @default.
- W1538863617 cites W2118300501 @default.
- W1538863617 cites W2118355238 @default.
- W1538863617 cites W2121320741 @default.
- W1538863617 cites W2122779695 @default.
- W1538863617 cites W2131370832 @default.
- W1538863617 cites W2144597667 @default.
- W1538863617 cites W2148336869 @default.
- W1538863617 cites W2152341263 @default.
- W1538863617 cites W2154988164 @default.
- W1538863617 cites W2157123954 @default.
- W1538863617 cites W2164085712 @default.
- W1538863617 cites W2170655291 @default.
- W1538863617 cites W2171827669 @default.
- W1538863617 cites W2232858378 @default.
- W1538863617 cites W2328753386 @default.
- W1538863617 cites W2568227459 @default.
- W1538863617 cites W3198624699 @default.
- W1538863617 cites W4205805944 @default.
- W1538863617 cites W4213156194 @default.
- W1538863617 cites W55856558 @default.
- W1538863617 doi "https://doi.org/10.1016/j.jcin.2012.06.008" @default.
- W1538863617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22995877" @default.
- W1538863617 hasPublicationYear "2012" @default.
- W1538863617 type Work @default.
- W1538863617 sameAs 1538863617 @default.
- W1538863617 citedByCount "206" @default.
- W1538863617 countsByYear W15388636172012 @default.
- W1538863617 countsByYear W15388636172013 @default.
- W1538863617 countsByYear W15388636172014 @default.
- W1538863617 countsByYear W15388636172015 @default.
- W1538863617 countsByYear W15388636172016 @default.
- W1538863617 countsByYear W15388636172017 @default.
- W1538863617 countsByYear W15388636172018 @default.
- W1538863617 countsByYear W15388636172019 @default.
- W1538863617 countsByYear W15388636172020 @default.
- W1538863617 countsByYear W15388636172021 @default.
- W1538863617 countsByYear W15388636172022 @default.
- W1538863617 countsByYear W15388636172023 @default.
- W1538863617 crossrefType "journal-article" @default.
- W1538863617 hasAuthorship W1538863617A5001027053 @default.
- W1538863617 hasAuthorship W1538863617A5003180371 @default.
- W1538863617 hasAuthorship W1538863617A5035216830 @default.
- W1538863617 hasAuthorship W1538863617A5042435666 @default.
- W1538863617 hasAuthorship W1538863617A5046097365 @default.
- W1538863617 hasAuthorship W1538863617A5050537243 @default.
- W1538863617 hasAuthorship W1538863617A5052130375 @default.
- W1538863617 hasAuthorship W1538863617A5053270731 @default.
- W1538863617 hasAuthorship W1538863617A5054453490 @default.
- W1538863617 hasAuthorship W1538863617A5055861900 @default.
- W1538863617 hasAuthorship W1538863617A5056134091 @default.
- W1538863617 hasAuthorship W1538863617A5061510316 @default.
- W1538863617 hasAuthorship W1538863617A5068102973 @default.
- W1538863617 hasAuthorship W1538863617A5073232153 @default.
- W1538863617 hasAuthorship W1538863617A5074605462 @default.
- W1538863617 hasAuthorship W1538863617A5076374312 @default.
- W1538863617 hasAuthorship W1538863617A5076817668 @default.
- W1538863617 hasAuthorship W1538863617A5077732078 @default.
- W1538863617 hasAuthorship W1538863617A5087456355 @default.
- W1538863617 hasConcept C126322002 @default.
- W1538863617 hasConcept C127413603 @default.
- W1538863617 hasConcept C141071460 @default.