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• W1538962595 startingPage "4969" @default.
• W1538962595 abstract "Memory B cells are a central component of humoral immunity, and yet little is known about their longevity in humans. Immune memory after smallpox vaccination (DryVax) is a valuable benchmark for understanding the longevity of B cell memory in the absence of re-exposure to Ag. In this study, we demonstrate that smallpox vaccine-specific memory B cells last for >50 years in immunized individuals. Virus-specific memory B cells initially declined postimmunization, but then reached a plateau approximately 10-fold lower than peak and were stably maintained for >50 years after vaccination at a frequency of approximately 0.1% of total circulating IgG(+) B cells. These persisting memory B cells were functional and able to mount a robust anamnestic Ab response upon revaccination. Additionally, virus-specific CD4(+) T cells were detected decades after vaccination. These data show that immunological memory to DryVax vaccine is long-lived and may contribute to protection against smallpox." @default.
• W1538962595 created "2016-06-24" @default.
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• W1538962595 date "2003-11-07" @default.
• W1538962595 modified "2023-10-13" @default.
• W1538962595 title "Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination" @default.
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• W1538962595 doi "https://doi.org/10.4049/jimmunol.171.10.4969" @default.
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