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- W1539076444 abstract "Cell signaling is known to be involved in the development and activation of many cancers, and has been the subject of abundant research in the field of cancer (Levitzki & Klein, 2010; Robinson-White & Stratakis, 2002). In response to extracellular and intracellular stimuli, protein kinase mediated pathways orchestrate the activation of cell signaling cascades to control cell growth, proliferation, differentiation and survival. However, there is tremendous complexity in tumor cell signaling (Iqbal et al., 2010). Signaling experiments have demonstrated that many different stimuli may activate the same pathways and many pathways interact (“cross talk”) to modify and influence the outcome of a specific extracellular signal. In particular, the protein kinase A (PKA) pathway has been viewed as the central hub in the mediation of signals in endocrine tumorigenesis (Robinson-White & Stratakis, 2002). Depending on the species, tissue, cell type and ligand involved, the PKA hub interacts with high versatility with the mitogen activated protein kinase (MAPK), protein kinase B (akt/PKB), protein kinase C (PKC) and Wnt pathways to promote endocrine and other tumor cell development and progression (Almeida et al., 2010; Robinson-White & Stratakis, 2002). The purpose of this review is to highlight recent findings on the involvement of the PKA cell signaling pathway in endocrine tumorigenesis, and to define current clinical strategies and future perspectives for the treatment of endocrine and other tumors." @default.
- W1539076444 created "2016-06-24" @default.
- W1539076444 creator A5058549535 @default.
- W1539076444 date "2012-06-05" @default.
- W1539076444 modified "2023-10-01" @default.
- W1539076444 title "Interactions of the Protein Kinase A Signaling Pathway: Implications for the Treatment of Endocrine and Other Tumors" @default.
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- W1539076444 cites W1963828781 @default.
- W1539076444 cites W1964165239 @default.
- W1539076444 cites W1966035396 @default.
- W1539076444 cites W1970741817 @default.
- W1539076444 cites W1976849281 @default.
- W1539076444 cites W1979938143 @default.
- W1539076444 cites W1980180010 @default.
- W1539076444 cites W1980792888 @default.
- W1539076444 cites W1987278019 @default.
- W1539076444 cites W1991016861 @default.
- W1539076444 cites W1994084738 @default.
- W1539076444 cites W1994726128 @default.
- W1539076444 cites W2001656004 @default.
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- W1539076444 cites W2012873066 @default.
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- W1539076444 cites W2020832324 @default.
- W1539076444 cites W2021421238 @default.
- W1539076444 cites W2023348498 @default.
- W1539076444 cites W2024914385 @default.
- W1539076444 cites W2024936447 @default.
- W1539076444 cites W2029616901 @default.
- W1539076444 cites W2032368255 @default.
- W1539076444 cites W2037846733 @default.
- W1539076444 cites W2040887126 @default.
- W1539076444 cites W2042743896 @default.
- W1539076444 cites W2047138016 @default.
- W1539076444 cites W2047597784 @default.
- W1539076444 cites W2053033245 @default.
- W1539076444 cites W2053369782 @default.
- W1539076444 cites W2053383702 @default.
- W1539076444 cites W2055667563 @default.
- W1539076444 cites W2058767837 @default.
- W1539076444 cites W2062833451 @default.
- W1539076444 cites W2064040681 @default.
- W1539076444 cites W2065940035 @default.
- W1539076444 cites W2071861522 @default.
- W1539076444 cites W2079253925 @default.
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- W1539076444 cites W2082889823 @default.
- W1539076444 cites W2089109393 @default.
- W1539076444 cites W2089476355 @default.
- W1539076444 cites W2090290392 @default.
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- W1539076444 cites W2092884086 @default.
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- W1539076444 cites W2096883084 @default.
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- W1539076444 cites W2119800239 @default.
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- W1539076444 cites W2125256278 @default.
- W1539076444 cites W2127952836 @default.
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- W1539076444 cites W2129860672 @default.
- W1539076444 cites W2130473918 @default.
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- W1539076444 cites W2136477311 @default.
- W1539076444 cites W2141010596 @default.
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- W1539076444 cites W2171966399 @default.
- W1539076444 cites W2185050872 @default.
- W1539076444 cites W2206452702 @default.
- W1539076444 cites W2305657814 @default.
- W1539076444 cites W2317721149 @default.
- W1539076444 cites W2335016894 @default.
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- W1539076444 doi "https://doi.org/10.5772/38035" @default.
- W1539076444 hasPublicationYear "2012" @default.
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