FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539118047> ?p ?o ?g. }

• W1539118047 endingPage "941" @default.
• W1539118047 startingPage "929" @default.
• W1539118047 abstract "Abstract The detection of molecular signatures of selection is one of the major concerns of modern population genetics. A widely used strategy in this context is to compare samples from several populations and to look for genomic regions with outstanding genetic differentiation between these populations. Genetic differentiation is generally based on allele frequency differences between populations, which are measured by FST or related statistics. Here we introduce a new statistic, denoted hapFLK, which focuses instead on the differences of haplotype frequencies between populations. In contrast to most existing statistics, hapFLK accounts for the hierarchical structure of the sampled populations. Using computer simulations, we show that each of these two features—the use of haplotype information and of the hierarchical structure of populations—significantly improves the detection power of selected loci and that combining them in the hapFLK statistic provides even greater power. We also show that hapFLK is robust with respect to bottlenecks and migration and improves over existing approaches in many situations. Finally, we apply hapFLK to a set of six sheep breeds from Northern Europe and identify seven regions under selection, which include already reported regions but also several new ones. We propose a method to help identifying the population(s) under selection in a detected region, which reveals that in many of these regions selection most likely occurred in more than one population. Furthermore, several of the detected regions correspond to incomplete sweeps, where the favorable haplotype is only at intermediate frequency in the population(s) under selection." @default.
• W1539118047 created "2016-06-24" @default.
• W1539118047 creator A5018816923 @default.
• W1539118047 creator A5031598048 @default.
• W1539118047 creator A5061239954 @default.
• W1539118047 creator A5064091393 @default.
• W1539118047 creator A5085558970 @default.
• W1539118047 date "2013-03-01" @default.
• W1539118047 modified "2023-10-14" @default.
• W1539118047 title "Detecting Signatures of Selection Through Haplotype Differentiation Among Hierarchically Structured Populations" @default.
• W1539118047 cites W1513618424 @default.
• W1539118047 cites W1526807484 @default.
• W1539118047 cites W1582348437 @default.
• W1539118047 cites W1964895626 @default.
• W1539118047 cites W1970005034 @default.
• W1539118047 cites W1980792369 @default.
• W1539118047 cites W1982220354 @default.
• W1539118047 cites W1989923963 @default.
• W1539118047 cites W1995865454 @default.
• W1539118047 cites W2009588715 @default.
• W1539118047 cites W2021810789 @default.
• W1539118047 cites W2025253353 @default.
• W1539118047 cites W2027688494 @default.
• W1539118047 cites W2034159975 @default.
• W1539118047 cites W2036507199 @default.
• W1539118047 cites W2036742645 @default.
• W1539118047 cites W2047366062 @default.
• W1539118047 cites W2047550265 @default.
• W1539118047 cites W2055543630 @default.
• W1539118047 cites W2058633835 @default.
• W1539118047 cites W2059165575 @default.
• W1539118047 cites W2062290915 @default.
• W1539118047 cites W2073994943 @default.
• W1539118047 cites W2081221567 @default.
• W1539118047 cites W2092574926 @default.
• W1539118047 cites W2092768543 @default.
• W1539118047 cites W2093044565 @default.
• W1539118047 cites W2097103181 @default.
• W1539118047 cites W2098298608 @default.
• W1539118047 cites W2100915101 @default.
• W1539118047 cites W2103286878 @default.
• W1539118047 cites W2104690544 @default.
• W1539118047 cites W2109183238 @default.
• W1539118047 cites W2109195195 @default.
• W1539118047 cites W2115837368 @default.
• W1539118047 cites W2118055782 @default.
• W1539118047 cites W2118484872 @default.
• W1539118047 cites W2124068663 @default.
• W1539118047 cites W2127864194 @default.
• W1539118047 cites W2134406094 @default.
• W1539118047 cites W2134599124 @default.
• W1539118047 cites W2135229958 @default.
• W1539118047 cites W2135370544 @default.
• W1539118047 cites W2138030838 @default.
• W1539118047 cites W2139451625 @default.
• W1539118047 cites W2147575903 @default.
• W1539118047 cites W2148278340 @default.
• W1539118047 cites W2152613935 @default.
• W1539118047 cites W2156866331 @default.
• W1539118047 cites W2156886335 @default.
• W1539118047 cites W2162157671 @default.
• W1539118047 cites W2163031152 @default.
• W1539118047 cites W2163980692 @default.
• W1539118047 cites W2165020636 @default.
• W1539118047 doi "https://doi.org/10.1534/genetics.112.147231" @default.
• W1539118047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3584007" @default.
• W1539118047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23307896" @default.
• W1539118047 hasPublicationYear "2013" @default.
• W1539118047 type Work @default.
• W1539118047 sameAs 1539118047 @default.
• W1539118047 citedByCount "261" @default.
• W1539118047 countsByYear W15391180472013 @default.
• W1539118047 countsByYear W15391180472014 @default.
• W1539118047 countsByYear W15391180472015 @default.
• W1539118047 countsByYear W15391180472016 @default.
• W1539118047 countsByYear W15391180472017 @default.
• W1539118047 countsByYear W15391180472018 @default.
• W1539118047 countsByYear W15391180472019 @default.
• W1539118047 countsByYear W15391180472020 @default.
• W1539118047 countsByYear W15391180472021 @default.
• W1539118047 countsByYear W15391180472022 @default.
• W1539118047 countsByYear W15391180472023 @default.
• W1539118047 crossrefType "journal-article" @default.
• W1539118047 hasAuthorship W1539118047A5018816923 @default.
• W1539118047 hasAuthorship W1539118047A5031598048 @default.
• W1539118047 hasAuthorship W1539118047A5061239954 @default.
• W1539118047 hasAuthorship W1539118047A5064091393 @default.
• W1539118047 hasAuthorship W1539118047A5085558970 @default.
• W1539118047 hasBestOaLocation W15391180471 @default.
• W1539118047 hasConcept C104317684 @default.
• W1539118047 hasConcept C105795698 @default.
• W1539118047 hasConcept C144024400 @default.
• W1539118047 hasConcept C149923435 @default.
• W1539118047 hasConcept C151730666 @default.
• W1539118047 hasConcept C154945302 @default.
• W1539118047 hasConcept C180754005 @default.
• W1539118047 hasConcept C197754878 @default.
• W1539118047 hasConcept C2776620128 @default.

• next