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- W1539132356 abstract "Process chemistry generally refers to the design and development of synthetic routes for the ultimate goal of manufacturing fine chemicals and, in particular, pharmaceuticals at commercial scale. This chapter presents a case study on developing a practical synthesis of cathepsin S inhibitor, a cysteine protease of the papain superfamily. Cathepsin S works to trigger an immune response. Therefore, cathepsin S inhibitors have been pursued by many pharmaceutical companies as a potential therapy for a range of immunological disorders. The authors devised a modular, highly efficient process to manufacture cathepsin S inhibitor from three easily accessible building blocks. This two-step synthesis is operationally simple, high yielding, and amenable to large-scale production. Although this route has a Sonogashira coupling in the final step of the synthesis, identification of an unusual, highly crystalline monoethyl oxalate salt form provided an efficient purification method for the final drug substance." @default.
- W1539132356 created "2016-06-24" @default.
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- W1539132356 date "2003-09-04" @default.
- W1539132356 modified "2023-10-17" @default.
- W1539132356 title "Practical Synthesis of a Cathepsin S Inhibitor" @default.
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- W1539132356 doi "https://doi.org/10.1002/9783527658909.ch05" @default.
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