Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539181208> ?p ?o ?g. }
- W1539181208 endingPage "1173" @default.
- W1539181208 startingPage "1166" @default.
- W1539181208 abstract "Fibroblasts cultured from patients completely deficient in hypoxanthine-guanine phosphoribosyltransferase activity were studied to determine the biochemical bases of the increased rate of purine biosynthesis de novo observed in such patients. Enzyme-deficient fibroblasts had accelerated rates of this pathway and elevated levels of 5-phosphoribosyl 1-pyrophosphate, although the rate of synthesis of this compound was not increased. These cells were sensitive to feedback inhibition of purine synthesis by nucleotides of adenine and 6-methylmercaptopurine ribonucleoside, but the rate of purine synthesis was increased by hypoxanthine and guanine. The concentrations of purine ribonucleotides in mutant cells were normal. The catabolism of inosinate synthesized de novo was increased in enzyme-deficient fibroblasts." @default.
- W1539181208 created "2016-06-24" @default.
- W1539181208 creator A5031449515 @default.
- W1539181208 creator A5037864999 @default.
- W1539181208 creator A5083691928 @default.
- W1539181208 creator A5085705318 @default.
- W1539181208 creator A5087378867 @default.
- W1539181208 date "1968-03-01" @default.
- W1539181208 modified "2023-10-16" @default.
- W1539181208 title "Biochemical Bases of Accelerated Purine Biosynthesis de Novo in Human Fibroblasts Lacking Hypoxanthine-Guanine Phosphoribosyltransferase" @default.
- W1539181208 cites W123782515 @default.
- W1539181208 cites W124940612 @default.
- W1539181208 cites W14054189 @default.
- W1539181208 cites W1488238606 @default.
- W1539181208 cites W1491814071 @default.
- W1539181208 cites W1505098764 @default.
- W1539181208 cites W1566297179 @default.
- W1539181208 cites W1600876026 @default.
- W1539181208 cites W1975147833 @default.
- W1539181208 cites W1976566711 @default.
- W1539181208 cites W1985212348 @default.
- W1539181208 cites W1986333903 @default.
- W1539181208 cites W1988962684 @default.
- W1539181208 cites W1993952908 @default.
- W1539181208 cites W1996661565 @default.
- W1539181208 cites W2008727921 @default.
- W1539181208 cites W2050527189 @default.
- W1539181208 cites W2050819982 @default.
- W1539181208 cites W2052610731 @default.
- W1539181208 cites W2053654911 @default.
- W1539181208 cites W2065759378 @default.
- W1539181208 cites W2089549345 @default.
- W1539181208 cites W2092342343 @default.
- W1539181208 cites W2101253062 @default.
- W1539181208 cites W2120613619 @default.
- W1539181208 cites W2123255145 @default.
- W1539181208 cites W2154349364 @default.
- W1539181208 cites W2323713083 @default.
- W1539181208 cites W2335432578 @default.
- W1539181208 cites W2341750029 @default.
- W1539181208 cites W4249182791 @default.
- W1539181208 cites W55110292 @default.
- W1539181208 cites W77466315 @default.
- W1539181208 cites W83471435 @default.
- W1539181208 cites W943953275 @default.
- W1539181208 doi "https://doi.org/10.1016/s0021-9258(19)56968-x" @default.
- W1539181208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5650894" @default.
- W1539181208 hasPublicationYear "1968" @default.
- W1539181208 type Work @default.
- W1539181208 sameAs 1539181208 @default.
- W1539181208 citedByCount "222" @default.
- W1539181208 countsByYear W15391812082012 @default.
- W1539181208 countsByYear W15391812082013 @default.
- W1539181208 countsByYear W15391812082014 @default.
- W1539181208 countsByYear W15391812082015 @default.
- W1539181208 countsByYear W15391812082016 @default.
- W1539181208 countsByYear W15391812082017 @default.
- W1539181208 countsByYear W15391812082018 @default.
- W1539181208 countsByYear W15391812082019 @default.
- W1539181208 countsByYear W15391812082020 @default.
- W1539181208 countsByYear W15391812082021 @default.
- W1539181208 countsByYear W15391812082023 @default.
- W1539181208 crossrefType "journal-article" @default.
- W1539181208 hasAuthorship W1539181208A5031449515 @default.
- W1539181208 hasAuthorship W1539181208A5037864999 @default.
- W1539181208 hasAuthorship W1539181208A5083691928 @default.
- W1539181208 hasAuthorship W1539181208A5085705318 @default.
- W1539181208 hasAuthorship W1539181208A5087378867 @default.
- W1539181208 hasBestOaLocation W15391812081 @default.
- W1539181208 hasConcept C104317684 @default.
- W1539181208 hasConcept C143065580 @default.
- W1539181208 hasConcept C169586020 @default.
- W1539181208 hasConcept C181199279 @default.
- W1539181208 hasConcept C185592680 @default.
- W1539181208 hasConcept C2776476023 @default.
- W1539181208 hasConcept C2777991568 @default.
- W1539181208 hasConcept C2778301229 @default.
- W1539181208 hasConcept C2781116151 @default.
- W1539181208 hasConcept C2909697302 @default.
- W1539181208 hasConcept C40507961 @default.
- W1539181208 hasConcept C512185932 @default.
- W1539181208 hasConcept C553450214 @default.
- W1539181208 hasConcept C55493867 @default.
- W1539181208 hasConcept C78179603 @default.
- W1539181208 hasConcept C86803240 @default.
- W1539181208 hasConceptScore W1539181208C104317684 @default.
- W1539181208 hasConceptScore W1539181208C143065580 @default.
- W1539181208 hasConceptScore W1539181208C169586020 @default.
- W1539181208 hasConceptScore W1539181208C181199279 @default.
- W1539181208 hasConceptScore W1539181208C185592680 @default.
- W1539181208 hasConceptScore W1539181208C2776476023 @default.
- W1539181208 hasConceptScore W1539181208C2777991568 @default.
- W1539181208 hasConceptScore W1539181208C2778301229 @default.
- W1539181208 hasConceptScore W1539181208C2781116151 @default.
- W1539181208 hasConceptScore W1539181208C2909697302 @default.
- W1539181208 hasConceptScore W1539181208C40507961 @default.
- W1539181208 hasConceptScore W1539181208C512185932 @default.
- W1539181208 hasConceptScore W1539181208C553450214 @default.