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• W1539187400 abstract "Alternative Oxidase genes encode a small family of isoenzymes (enzymes with some differences but act in the same chemical reaction). AOX is present in plants, fungi, algae, some yeast, and was also found in some classes of the animal kingdom. The enzymes are responsible for an alternative pathway of respiration that is responsive to stress conditions but also to pathogen attack, as well as growth and stage development. Scaffold Matrix Attachment Regions (S/MARs) are DNA sequences from 300 to 3000 nucleotides that bound with nuclear proteins serving as anchors for DNA, influencing in this way the DNA organization inside the cell. Several studies have failed to reveal a pattern of organization in the sequences, however some rules have been found that help computer based analysis. Experimental identification of these sequences is hard and time consuming, computer methods could provide a first step selection, and cover larger sequences. In order to highlight possible links between S/MARs and differential regulation of AOX genes, the first part of this project consists in identifying structurally relevant S/MAR regions in the neighborhood of AOX genes in Arabidopsis thaliana and in rice using a selected computer program. Single Nucleotide Polymorphisms (SNPs) are variations in one nucleotide base among DNA sequences from the same location, from different individuals. These differences could serve as markers to classify a specific set of individuals. The second part of this project consists in the development of a bioinformatic application that will help in the identification of specific polymorphisms (SNPs) in sequences that are experimentally obtained at the EU Marie Curie Chair in ICAM University of Evora, where this project is performed." @default.
• W1539187400 created "2016-06-24" @default.
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• W1539187400 date "2007-01-01" @default.
• W1539187400 modified "2023-09-27" @default.
• W1539187400 title "BIOINFORMATIC STUDIES ON STRUCTURAL ELEMENTS FOR THE REGULATION OF ALTERNATIVE OXIDASE (AOX) GENE ACTIVITIES" @default.
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